N/A
N=33
RAAS and Arterial Stiffness in SCI
Arterial Stiffness · Renin Angiotensin Aldosterone System · Orthostatic Hypotension · Spinal Cord Injury · Hypotension
Bottom Line
View on ClinicalTrials.gov: NCT04510974 ↗Enrolled (actual)
33
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcome: Primary: Pulse Wave Velocity (m/s) — 8.81; 7.36; 5.53 m/s
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Spinal Cord Injury (Other)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- James J. Peters Veterans Affairs Medical Center
- Primary completion
- Dec 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pulse Wave Velocity (m/s) |
8.81; 7.36; 5.53 | — |
| SECONDARY Systolic Blood Pressure (mmHg) |
95; 125; 128 | — |
| SECONDARY Plasma Renin (pg/ml) |
24.9; 21.9; 16.0 | — |
| SECONDARY Norepinephrine (pg/ml) |
176.0; 515.6; 371.8 | — |
Summary
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
Eligibility Criteria
Inclusion Criteria
- SCI participants:
- injured between C1-T1 and T6-T12
- wheelchair dependent
- AIS classification A, B or C
- Injured occurred more than 1 year ago
Exclusion Criteria
- currently have an illness or infection
- current smoker of at least 1 year
- controlled or uncontrolled hypertension or diabetes mellitus
- Neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease)
- cardiovascular disease (coronary heart disease, congestive heart failure, peripheral artery disease)
Data sourced from ClinicalTrials.gov (NCT04510974). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.