N/A
N=41
Cardiovascular Responses to Heat Waves in the Elderly
Aging · Hyperthermia
Bottom Line
View on ClinicalTrials.gov: NCT04538144 ↗Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcome: Primary: Change in Core Body Temperature — .68; 1.37; .58; 1.02 degrees Celsius (°C)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Hot and Humid Trial (Other); Hot and Dry Trial (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Texas Southwestern Medical Center
- Primary completion
- Feb 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Core Body Temperature |
.68; 1.37; .58; 1.02 | — |
| PRIMARY Change in Peak Mitral Annular Systolic Velocity (S') |
1.46; 3.33; 1.39; 2.09 | — |
| SECONDARY Ending Skin Temperature |
37.57; 37.37; 36.65; 36.05 | — |
| SECONDARY Ending Heart Rate |
82; 87; 80; 81 | — |
| SECONDARY Ending Mean Arterial Pressure |
77; 76; 78; 76 | — |
| SECONDARY Change in Cardiac Output |
.88; .75; .38; .76 | — |
Summary
The purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions
Eligibility Criteria
Inclusion Criteria
- Healthy male and female individuals
- 18-35 years or 65+ years of age
- Free of any underlying moderate to serious medical conditions
Exclusion Criteria
- Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia.
- Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses.
- Abnormalities detected on routine screening.
- Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
- Current smokers, as well as individuals who regularly smoked within the past 3 years.
- Body mass index of greater than 30 kg/m^2
- Pregnant individuals
Data sourced from ClinicalTrials.gov (NCT04538144). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.