Mode
Text Size
Log in / Sign up
N/A N=91 Randomized Single-blind Treatment

Examining a Digital Health Approach for Advancing Schizophrenia Illness Self-management and Provider Engagement

Schizophrenia · Schizo Affective Disorder · Psychotic Disorders

Enrolled (actual)
91
Serious AEs
0.0%
Results posted
May 2026
Primary outcome: Primary: Recruitment — 91 Participants

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
A4i Intervention (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Centre for Addiction and Mental Health
Primary completion
Jun 2023

Outcome Measures

OutcomeResultp-value
PRIMARY
Recruitment
91
PRIMARY
Retention
26; 41
PRIMARY
App Interactions
14.9
PRIMARY
Incidence of Treatment-Emergent Adverse Events
0; 0
PRIMARY
App Likes
24.6
SECONDARY
BSI: Psychiatric Symptoms
53.0; 61.5; 39.4; 53.3; -13.7; -7.4
SECONDARY
BARS: Medication Adherence
17; 23; 3; 3; 23; 22
SECONDARY
STAR-P: Patient Relationship With Clinician
39.3; 37.0; 38.0; 36.1; -0.9; -1.9
SECONDARY
QLS: Heinrichs-Carpenter Quality of Life Scale
77.4; 79.2; 63.2; 70.1; -4.6; 4.2
SECONDARY
PANSS: Schizophrenia Symptoms
54.0; 56.1; 48.0; 45.1; -6.1; -10.2
SECONDARY
GAIN-SS
5.1; 5.8; 3.3; 5.1; -1.2; 0.2
SECONDARY
MOS: Treatment Adherence - General
25.5; 23.2; 23.2; 23.0; -2.1; -0.5
SECONDARY
Appointment Attendance
82; 84; 11; 9
SECONDARY
STAR-C: Clinician Relationship With Patient
36.2; 36.9; 20.8; 17.4; -3.2; -0.9
SECONDARY
SUH - Patients
5.3; 3.8; 1.8; 4.2; 3.6; 3.9
SECONDARY
SUH - Clinicians
1.1; 0.8; 1.7; 1.7; 6.4; 8.1

Summary

The effective treatment of schizophrenia is very challenging due to a number of factors. These include issues such as poor engagement with treatment plans and care providers, limited contacts with providers due to under-resourced health services, and the challenges inherent to schizophrenia symptoms. The outcomes of these problems include frequent, lengthy, and costly hospital readmissions, low quality of life, high levels of distress, and difficulties engaging in valued community roles. Digital Health technologies are a promising model to help address these problems. They are a low cost and accessible form of support and have not been substantively developed or studied for people with schizophrenia spectrum illnesses. In this study, the feasibility of one such technology that is in development will be tested: App4Independence (A4i). A4i provides customized coping prompts, peer-peer networking, and a portal that facilitates better provider engagement. This research will provide critical information in the development of this new technology to address a key problem in the field - how to enhance care in a resource-limited context where provider-patient contacts are brief, infrequent, and rely on in the moment recall and self-advocacy by patients. These findings will lay the groundwork for a larger program of research and software development that will (i) validate the technology across multiple sites and, (ii) catalyze engagement with healthcare systems and caregiver networks to scale-out access to this promising resource.

Eligibility Criteria

Inclusion Criteria

  • Participants will be adults, 18 years of age or older, with a chart diagnosis of a DSM-5 schizophrenia spectrum illness confirmed by a structured diagnostic interview (SCID-5)40.
  • All participants will be engaged in outpatient psychiatric treatment.
  • Proficiency in English.
  • Own and use an Android or iOS smartphone.

Exclusion Criteria

  • Lack of capacity with no identified substitute decision maker.
  • Intellectual disability.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04602741). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

Back to search