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Home › Conditions › Psychotic disorders

Psychotic disorders

Part of Psychosis

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Psychotic disorders

51 trials tracked for Psychotic disorders: 15 in phase 3 or 4 and 2 with published results. The most-cited published study has 22 citations.

51Trials tracked
15Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 10 Phase 3 5 Phase 2 4 Phase 1 4 Other / NA 28
  1. Phase 4 Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics Completed · 22 cited
  2. Phase 3 A Study to Compare Disease Progression and Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics in Participant's With Recent-onset Schizophrenia or Schizophreniform Completed · 14 cited
  3. Phase 4 Risperidone Long-acting Versus Oral Risperidone in Patients With Schizophrenia and Alcohol Use Disorder Completed
  4. Phase 4 Effectiveness of Pimozide in Augmenting the Effects of Clozapine in the Treatment of Schizophrenia Completed
  5. Phase 4 Evaluation of Effectiveness of Risperdal® Consta® Compared to Abilify® Over a Two-year Period in Patients With Schizophrenia Completed
  6. Phase 4 Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder Completed
Show 44 more trials
  1. Phase 4 Study to Measure the Safety of Paliperidone ER (Extended-release) in Patients With Liver Disease Completed
  2. Phase 4 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed
  3. Phase 4 Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual Completed
  4. Phase 4 Antipsychotic Discontinuation in Alzheimer's Disease Completed
  5. Phase 4 A Trial Comparing Risperidone Long-Acting Injection With Oral Antipsychotic in the Treatment of Early Psychosis Completed
  6. Phase 3 Evaluation of Effectiveness and Safety of Paliperidone Extended Release in Patients With Schizoaffective Disorder. Completed
  7. Phase 3 Open-label Study of Flexible-dose Paliperidone ER (Extended Release) to Treat Adolescent Schizophrenia. Completed
  8. Phase 3 A Study of Relapse Prevention and the Effectiveness of Long-acting Injectable Risperidone and Quetiapine Tablets in the Treatment of Patients With Schizophrenia or Schizoaffective Disorder Completed
  9. Phase 3 Evaluation of Effectiveness and Safety of Flexible-dose Paliperidone Extended Release in Patients With Schizoaffective Disorder. Completed
  10. Phase 2 Melperone (an Anti-Psychotic) in Patients With Psychosis Associated With Parkinson's Disease Completed
  11. Phase 2 Supported Employment: Motivational Enhancement for Entry and Outcome Completed
  12. Phase 2 Treating Smokers With Mental Illness Completed
  13. Phase 2 Pentosan Polysulfate Sodium and Meclofenamic Acid as Treatments in Patients With Psychotic Disorders Completed
  14. Phase 1 Weight Management Program for Patients With First Episode Psychosis Completed
  15. Phase 1 Cannabis and Schizophrenia: Self-Medication and Agonist Treatment Completed
  16. Phase 1 Acceptance and Commitment Therapy for the Inpatient Treatment of Psychosis Completed
  17. Phase 1 Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment? Completed
  18. N/A Transcranial Brain Stimulation and Its Underlying Neural Mechanisms as a Novel Treatment for Auditory Hallucinations Completed
  19. N/A Peer Support for Exercise in Older Veterans With Psychotic Disorders Completed
  20. N/A Examining a Digital Health Approach for Advancing Schizophrenia Illness Self-management and Provider Engagement Completed
  21. N/A A Brief Community Linkage Intervention for Dually Diagnosed Individuals Completed
  22. N/A The Family VOICE Study Completed
  23. N/A iTEST: Introspective Accuracy as a Novel Target for Functioning in Psychotic Disorders Completed
  24. N/A Mobile After-Care Intervention to Support Post-Hospital Transition (MACS) Completed
  25. N/A Impact of VVV Group for Veterans With SMI Completed
  26. N/A Psychosis Screening in Juvenile Justice Completed
  27. N/A Implementing Effective, Collaborative Care for Schizophrenia (EQUIP-2) Completed
  28. N/A Web-Based Delivery of MOVE! to Veterans With Serious Mental Illness (SMI) Completed
  29. N/A First Episode Schizophrenia and Cannabis-Related Disorder Study Completed
  30. N/A Acute Glycine Pharmacodynamic Study Completed
  31. N/A Psychosis: Early Detection, Intervention and Prevention Completed
  32. N/A Functional Rehabilitation of Older Patients With Schizophrenia Completed
  33. N/A A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness Completed
  34. N/A Facilitating Engagement in Evidence-Based Treatment for Early Psychosis Completed
  35. N/A Early Detection and Intervention for the Prevention of Psychosis Completed
  36. N/A Mindfulness Meditation as a Rehabilitation Strategy for Persons With Schizophrenia Completed
  37. N/A Reproductive Life Planning for Women With Mental Illness Completed
  38. N/A Pilot Study of Motivational Interviewing for Loved Ones Completed
  39. N/A Yoga and Aerobic Exercise in Psychosis Completed
  40. N/A Monitoring and Management for Metabolic Side Effects of Antipsychotics Completed
  41. N/A Mobile After-Care Support App: Pilot RCT Completed
  42. N/A A Patient-Centered Approach to Improve Screening for Side Effects of Second Generation Antipsychotics (SGAs) Completed
  43. N/A Skills Training to Enhance Vocational Outcomes in Veterans With Serious Mental Illness Completed
  44. N/A Decision Support for Smoking Cessation in Young Adults With Severe Mental Illness Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries
Psychiatry Meta-analysis
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries Half of Schizophrenia Patients Take Multiple Drugs at Once
This systematic review and meta-analysis of 17 studies (6,053 individuals) from MENAT/EMRO countries found a pooled prevalence of antipsycho…
New data reveals half of patients with schizophrenia in the Middle East take multiple antipsychotic drugs at once.
Frontiers Apr 29, 2026
Systematic review of dance/movement therapy for psychotic and eating disorders
Psychiatry Meta-analysis
Systematic review of dance/movement therapy for psychotic and eating disorders Dance therapy shows promise for teens and adults with mental health challenges
This systematic review of 12 studies examined dance/movement therapy as an adjunctive intervention for adolescents or adults with psychotic …
A review of 12 studies suggests dance and movement therapy can help people with psychotic or eating disorders feel more connected and emotio…
Frontiers Apr 24, 2026
Cognitive Remediation Therapy Re-analysis Shows Benefit Over Treatment As Usual on Global Assessment Scale
Psychiatry RCT
Cognitive Remediation Therapy Re-analysis Shows Benefit Over Treatment As Usual on Global Assessment Scale When Patients Rank Treatment Success Differently Than Doctors
This re-analysis of a randomized controlled trial evaluated Cognitive Remediation Therapy versus treatment as usual among participants and s…
Patients and doctors value different treatment benefits, and letting patients help decide what counts as success can change how we understan…
Apr 19, 2026
In children with first psychotic symptoms, 23.5% had substance- or medically-associated psychosis after extensive workup
Psychiatry Cohort
In children with first psychotic symptoms, 23.5% had substance- or medically-associated psychosis after extensive workup Medical testing found substance or medical causes in 23.5% of youth with new psychosis
This retrospective cohort study evaluated 68 children and adolescents admitted for a first presentation of psychotic symptoms at a tertiary …
Medical testing found substance or medical causes in 23.5% of youth with new psychosis, proving a thorough workup is essential before diagno…
Frontiers Apr 16, 2026

Questions about Psychotic disorders

Does cognitive remediation therapy work better than standard care for psychotic disorders?

Cognitive remediation therapy (CRT) shows significant benefits over standard care for people with psychotic disorders, improving global functioning and quality of life.

Full answer →