N/A
Completed N=157
Improving Treatment Outcomes for Suicidal Veterans With PTSD
Suicidal Ideation · Suicide, Attempted · Post-Traumatic Stress Disorder
Source: ClinicalTrials.gov NCT04690582 ↗
Enrolled (actual)
157
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcomePrimary: Change in Suicide Ideation — 5.91; 6.37; 3.67; 2.47 units on a scale
Summary
The efficacy of cognitive processing therapy (CPT) for reducing the symptoms of posttraumatic stress disorder (PTSD) across populations including military personnel and veterans is well supported. CPT also contributes to significant and rapid reductions in suicide ideation among people diagnosed with PTSD, although available evidence suggests this effect decays over time. Studies also show that approximately 1 in 6 people who begin CPT without suicide ideation will subsequently report suicidal thoughts at some point during or soon after completing treatment. Research focused on improving CPT's effects on suicide risk is therefore warranted. The primary aim of this study is to determine if the integration of a crisis response plan (CRP)--an empirically-supported procedure for reducing suicide ideation and attempts--can lead to faster reductions in suicide ideation among acutely suicidal veterans receiving CPT and prevent the development of suicide ideation among veterans who begin CPT without suicide ideation.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Suicide Ideation |
5.91; 6.37; 3.67; 2.47; 3.00; 2.25 | — |
| PRIMARY Percent With Follow-up Suicidal Behaviors |
4; 3 | — |
| PRIMARY Number of Follow-up Suicidal Behaviors |
8; 4 | — |
| SECONDARY Change in PTSD Symptoms |
27.01; 25.93; 17.57; 18.05; 13.42; 13.06 | — |
Eligibility Criteria
Inclusion Criteria
- 18 years of age or older
- Current or prior service in the U.S. military
- Current diagnosis of PTSD or subthreshold PTSD
- Ability to speak and understand the English language
- Ability to complete the informed consent process.
Exclusion Criteria
- Substance use disorder requiring medical management
- Imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment
- Impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania)
Data sourced from ClinicalTrials.gov (NCT04690582). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.