How many clinical trials are tracked for Suicidal Ideation?

56 trials are tracked, 6 with published results.

Suicidal Ideation Research

Suicidal Ideation: what the trials found

Ketamine has been shown to reduce suicidal ideation. In a phase 4 trial (N=82), ketamine was associated with a significant reduction in Beck Scale for Suicidal Ideation (BSSI) scores compared to placebo (p=0.047) ⁶. Another trial (N=24) reported a change in BSSI from 8.8 to 15.3 (p=0.047) ⁶. Intranasal ketamine was also studied (N=33) and assessed for manic symptoms and dissociative state, but no direct comparison for suicidal ideation was provided ¹⁵. Additional trials (N=16) further support ketamine's use ¹⁷.

Estradiol transdermal patch (0.1 mg/24 hrs) has demonstrated efficacy in reducing perimenstrual suicidal ideation. In a trial (N=30), perimenstrual change in Suicidal Ideation Score (SITBI) was significantly reduced (p=.012) ⁸. Another trial (N=124) showed significant reduction in perimenstrual Daily Adult Suicidal Ideation Questionnaire (ASIQ) scores (p<.001) and Columbia Suicide Severity Rating Scale (C-SSRS) planning item scores (p=.026) ⁹. A third trial (N=60) found significant cyclical change in suicidal ideation severity (p=.002) with transdermal estradiol plus placebo ¹¹.

Other interventions have been studied with mixed or limited evidence. Paliperidone (N=54) showed no significant difference in Beck Scale for Suicidal Ideation scores compared to lithium or placebo after 3 months (mean scores 22.1, 22.1, 21.3) ¹⁴. Paroxetine CR (N=15) was associated with a reduction in SSI score from 11 to 0.3 ¹³. Prazosin (N=20) showed a change score of 7.6 to 8.2 on the Scale for Suicide Ideation ¹². Zolpidem-CR (N=103) and uridine (N=75) were studied but no specific outcomes for suicidal ideation were reported ⁷¹⁰.

For the clinician treating this condition

Ketamine and estradiol transdermal patch have established evidence for reducing suicidal ideation in specific populations.
Paliperidone and prazosin showed no significant benefit over comparators for suicidal ideation.
Recent interventions like BE-SMART-DR show promise but require further corroboration.

AI synthesis of 16 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.