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Home › Conditions › Suicidal Ideation

Suicidal Ideation

Part of Suicide

11 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Suicidal Ideation

56 trials tracked for Suicidal Ideation: 11 in phase 3 or 4 and 6 with published results. The most-cited published study has 428 citations.

56Trials tracked
11Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 10 Phase 3 1 Phase 2 2 Other / NA 43
  1. Phase 4 Ketamine in the Treatment of Suicidal Depression Completed · 428 cited
  2. Phase 4 Ketamine For Suicidal Ideation Completed · 297 cited
  3. Phase 4 Reducing Suicidal Ideation Through Insomnia Treatment Completed · 152 cited
  4. Phase 4 Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality Completed · 42 cited
  5. Phase 3 Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse Completed · 13 cited
  6. Phase 4 Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality Completed
Show 44 more trials
  1. Phase 4 Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study Completed
  2. Phase 4 Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD) Completed
  3. Phase 4 Clinical and Imaging Trial of Uridine for Veterans With Suicidal Ideation Completed
  4. Phase 4 Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach Completed
  5. Phase 4 Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation Completed
  6. Phase 2 Ketamine for Suicidality in Bipolar Depression Completed
  7. Phase 2 Sequential Therapy for the Treatment of Severe Bipolar Depression. Completed
  8. N/A Peer Mentorship to Reduce Suicide Attempts Among High-Risk Adults Completed
  9. N/A Career Enhancement Training Study (USAF) Completed
  10. N/A Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens) Completed
  11. N/A Mobile Technology for Reducing and Preventing Adolescent Suicide Completed
  12. N/A Text 2 Connect- Texting Intervention for Mental Health Treatment Utilization Completed
  13. N/A Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI) Completed
  14. N/A RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts Completed
  15. N/A Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders Completed
  16. N/A BRITEPath- Phase 2 Completed
  17. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Completed
  18. N/A Dialectical Behavior Therapy Skills Group Pilot Evaluation Completed
  19. N/A Drivers of Suicide Mobile App Study Completed
  20. N/A Improving Treatment Outcomes for Suicidal Veterans With PTSD Completed
  21. N/A A Trauma-Informed Approach for Positive Youth Development for Montana Students Completed
  22. N/A Navigating Mental Health Treatment for Black Youth Completed
  23. N/A Screening Wizard- Phase 2 Completed
  24. N/A Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms Completed
  25. N/A Treatment of Suicidal Ideation With Intravenous Ketamine Infusion Completed
  26. N/A Establishing Efficacy of an Inpatient Intervention and Phone App to Reduce Suicidal Risk Completed
  27. N/A Skills to Enhance Positive Affect in Suicidal Adolescents Completed
  28. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot Completed
  29. N/A Social Connections and Late Life Suicide Completed
  30. N/A BRITEPath, Component 3 of iCHART (Integrated Care to Help At-Risk Teens) Completed
  31. N/A Safety Planning in Juvenile Justice for Suicidal Youth Completed
  32. N/A Written vs Electronic Safety Planning Study Completed
  33. N/A UH3 Pragmatic Suicide Prevention Trial Completed
  34. N/A Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools Completed
  35. N/A Pilot RCT of a Video-based Intervention for Suicide Prevention Completed
  36. N/A Observational Study to Compare Outcomes of Different Psychiatric Treatment of Suicidal Adolescents Completed
  37. N/A Virtual Hope Box - Effectiveness of a Smartphone App for Coping With Suicidal Ideation Completed
  38. N/A Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth Completed
  39. N/A Screening Wizard, Component 1 of iCHART (Integrated Care to Help At-Risk Teens)-Feasibility/Pilot Phase Completed
  40. N/A Digital Mental Health Service for Non-Treatment Seeking Young Adults Completed
  41. N/A Group Depression Treatment for Autistic Youth Completed
  42. N/A Motivational Interviewing to Prevent Suicide in High Risk Veterans Completed
  43. N/A The Elders' Resilience Curriculum Completed
  44. N/A TMS for Suicidal Crisis in Active Duty SMs Completed

Showing the 50 most-cited and recently-updated of 56 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Suicidal Ideation: what the trials found

Ketamine has been shown to reduce suicidal ideation. In a phase 4 trial (N=82), ketamine was associated with a significant reduction in Beck Scale for Suicidal Ideation (BSSI) scores compared to placebo (p=0.047) 6. Another trial (N=24) reported a change in BSSI from 8.8 to 15.3 (p=0.047) 6. Intranasal ketamine was also studied (N=33) and assessed for manic symptoms and dissociative state, but no direct comparison for suicidal ideation was provided 15. Additional trials (N=16) further support ketamine's use 17.

Estradiol transdermal patch (0.1 mg/24 hrs) has demonstrated efficacy in reducing perimenstrual suicidal ideation. In a trial (N=30), perimenstrual change in Suicidal Ideation Score (SITBI) was significantly reduced (p=.012) 8. Another trial (N=124) showed significant reduction in perimenstrual Daily Adult Suicidal Ideation Questionnaire (ASIQ) scores (p<.001) and Columbia Suicide Severity Rating Scale (C-SSRS) planning item scores (p=.026) 9. A third trial (N=60) found significant cyclical change in suicidal ideation severity (p=.002) with transdermal estradiol plus placebo 11.

Other interventions have been studied with mixed or limited evidence. Paliperidone (N=54) showed no significant difference in Beck Scale for Suicidal Ideation scores compared to lithium or placebo after 3 months (mean scores 22.1, 22.1, 21.3) 14. Paroxetine CR (N=15) was associated with a reduction in SSI score from 11 to 0.3 13. Prazosin (N=20) showed a change score of 7.6 to 8.2 on the Scale for Suicide Ideation 12. Zolpidem-CR (N=103) and uridine (N=75) were studied but no specific outcomes for suicidal ideation were reported 710.

Recent results — preliminary, needs further review

  • Adapted STAT-ED (N=54) is being investigated for suicidal ideation 1.
  • WisePath for Adults (N=127) is a recent intervention under study 2.
  • BE-SMART-DR (N=65) showed significant reductions in suicidal ideation/propensity as measured by CHRT-SR (p=0.0008) and SSI (p<.0001), and improved daily rhythms (p=0.0002) 3.
  • Adaptive messaging intervention (N=120) is being explored 4.
  • Making Connections Intervention (N=29) is a recent approach 18.

For the clinician treating this condition

  • Ketamine and estradiol transdermal patch have established evidence for reducing suicidal ideation in specific populations.
  • Paliperidone and prazosin showed no significant benefit over comparators for suicidal ideation.
  • Recent interventions like BE-SMART-DR show promise but require further corroboration.

AI synthesis of 16 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Childhood psychological abuse is significantly associated with suicidal ideation in college students
Pediatrics Meta-analysis
Childhood psychological abuse is significantly associated with suicidal ideation in college students Childhood Psychological Abuse Linked to Suicidal Ideation in Students
This meta-analysis of 31 studies involving 862,132 participants found that childhood psychological abuse is positively and significantly ass…
A large-scale review of data from over 800,000 students links childhood psychological abuse and sexual abuse to higher rates of suicidal tho…
Jul 2, 2026
Narrative review highlights distinct biological processes in pediatric suicidal behavior compared to adults
Pediatrics Sys. Review
Narrative review highlights distinct biological processes in pediatric suicidal behavior compared to adults Biological markers of youth suicide differ from adults
This narrative review examines biological signatures of suicidal ideation, suicide attempts, and death by suicide in pediatric and adolescen…
A review suggests biological signs of suicidal thoughts in children and teens are distinct from adults, meaning adult data cannot explain yo…
Frontiers May 28, 2026
Multimodal stepped-prevention program fails to reduce suicidal thoughts in adolescents
Psychiatry RCT
Multimodal stepped-prevention program fails to reduce suicidal thoughts in adolescents Depression Prevention Program Fails to Reduce Suicidal Thoughts in Teens
This cluster RCT in 1593 adolescents from 15 Dutch high schools found that a multimodal stepped-prevention program did not reduce suicidal t…
A school-based program to prevent depression and suicide in teens did not reduce symptoms and may have increased them, possibly due to COVID…
medRxiv May 7, 2026
Cross-sectional evaluation finds supervisory system improves suicide risk detection in LLMs
Psychiatry
Cross-sectional evaluation finds supervisory system improves suicide risk detection in LLMs AI Chatbots Often Miss Suicide Risk. A New Safety Layer Could Change That
A cross-sectional evaluation of 224 paired suicide-related clinical vignettes compared an independent supervisory safety architecture with a…
Adding a separate safety monitor to AI chatbots could prevent them from missing signs of suicide risk, making digital mental health tools sa…
medRxiv Apr 22, 2026
Survey examines suicidal ideation and behaviors among U.S. high school students
Infectious Disease
Survey examines suicidal ideation and behaviors among U.S. high school students Survey examines suicidal thoughts and behaviors among U.S. high school students
An observational survey report describes suicidal ideation and behaviors among high school students in the United States.
A recent survey of U.S. high school students examined their experiences with suicidal thoughts and behaviors, highlighting ongoing research …
CDC Apr 6, 2026
Observational study finds association between violence/harassment and suicidal ideation in transgender women
Infectious Disease
Observational study finds association between violence/harassment and suicidal ideation in transgender women Study explores link between violence, harassment and suicidal thoughts in transgender women
An observational study of transgender women in seven U.S.
Transgender women facing violence or harassment show higher rates of suicidal thoughts, though strong social support may help lessen this li…
CDC Apr 5, 2026
Survey examines mental health, suicide risk, and protective factors in US high school students
Psychiatry
Survey examines mental health, suicide risk, and protective factors in US high school students What protects high school students' mental health? A new survey looks for answers
A US survey report describes mental health and suicide risk among high school students, along with health-promoting behaviors and protective…
A new survey shifts focus from teen mental health crises to the everyday habits and relationships that might be protecting high school stude…
CDC Apr 3, 2026
U.S. population suicide rates increased during 2021, observational report finds
Psychiatry
U.S. population suicide rates increased during 2021, observational report finds Report shows suicide rates increased in the United States during 2021
An observational report on the U.S. population found suicide rates increased during 2021.
Suicide rates increased across the United States in 2021, a concerning pattern that requires continued attention and resources.
CDC Apr 3, 2026
Report provides estimates on U.S. adults knowing suicide decedents and experiencing suicidal thoughts
Psychiatry
Report provides estimates on U.S. adults knowing suicide decedents and experiencing suicidal thoughts Report looks at suicide exposure and thoughts among U.S. adults
An observational report provides estimates for the proportion of U.S.
A new report reveals how many U.S. adults have known someone who died by suicide and how many have experienced suicidal thoughts themselves.
CDC Apr 3, 2026
Mental health symptoms and suicidal ideation reported among US public health workers
Psychiatry
Mental health symptoms and suicidal ideation reported among US public health workers CDC report examines mental health symptoms among U.S. public health workers
An observational report describes symptoms of mental health conditions and suicidal ideation among state, tribal, local, and territorial pub…
A new CDC report examines mental health conditions and thoughts of suicide among public health workers across the United States.
CDC Apr 3, 2026
Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD
Psychiatry RCT
Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD Study protocol tests brain stimulation for depression with suicidal thoughts
This is a study protocol for a single-blind RCT of 56 adults with major depressive disorder and active suicidal ideation.
A new brain stimulation treatment is being tested to reduce depression and suicidal thoughts in adults, using magnetic pulses over 10 sessio…
Frontiers Apr 1, 2026