N/A
Completed N=38
Cognitive Fitness for Depression in Older Adults
Depression Mild · Depressive Disorder, Major · Mild Cognitive Impairment
Source: ClinicalTrials.gov NCT04790630 ↗
Enrolled (actual)
38
Serious AEs
3.0%
Results posted
Apr 2026
Primary outcomePrimary: Trail Making Part B Test — 5.06; -1.55 seconds
Summary
This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Trail Making Part B Test |
5.06; -1.55 | — |
| PRIMARY Montgomery Asberg Depression Rating Scale (MADRS) |
-4.40; -2.61 | — |
| SECONDARY California Verbal Learning Test (CVLT) Total Learning |
3.08; 4.40 | — |
| SECONDARY NIH Toolbox Pattern Comparison Speed Task |
11.44; 2.20 | — |
Eligibility Criteria
Inclusion Criteria
- ability to read and write in English
- current major or mild depression despite ongoing treatment
- under the care of a physician who prescribes medication for depression
- currently treated with an antidepressant for at least 8 weeks
Exclusion Criteria
- psychosis
- other psychiatric disorders (except personality & generalized anxiety disorders)
- substance use disorders in the prior year
- clinical diagnosis of dementia
- neurological disorders (e.g., stroke, epilepsy, brain injury with loss of consciousness > 30 minutes, brain tumors, demyelinating diseases)
- corrected visual acuity < 20/70 or color blindness
Data sourced from ClinicalTrials.gov (NCT04790630). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.