N/A
N=81
LIFT Intervention in Liver Transplant Candidates
Frailty · Cirrhosis · Liver Transplant
Bottom Line
View on ClinicalTrials.gov: NCT04836923 ↗Enrolled (actual)
81
Serious AEs
0.0%
Results posted
May 2026
Primary outcome: Primary: Frailty — 3.63; 3.48 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- "LIver FrailTy" intervention (LIFT) (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Northwestern University
- Primary completion
- Mar 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Frailty |
3.63; 3.48 | — |
| PRIMARY Patient-reported Physical Function |
46.6; 46.7 | — |
| PRIMARY Exercise Adherence Rate |
62; 60; 51 | — |
| SECONDARY Clinical Outcomes - Liver Related Complications |
54; 0 | — |
Summary
Frailty is a significant problem in patients undergoing liver transplant and is associated with poor outcomes and survival. Hence, optimizing physical fitness and counteracting frailty is important. However, many interventions are very resource intensive and therefore not feasible.
In this study, the investigators aim to test the effectiveness of a newly designed intervention to improve frailty in liver transplant candidates. The "LIver FrailTy" intervention (LIFT) will consist of an evaluation by a physical therapist, an individualized home exercise prescription (HEP), exercise tracking using a smart phone application, daily text reminders to exercise and recurrent telephone check-ins.
Eligibility Criteria
Inclusion Criteria
- Patients with a diagnosis of liver cirrhosis being evaluated for liver transplantation in hepatology/transplant evaluation clinic
- English-speaking
- Patients with access to a smart phone (with videoconference capabilities)
- Vulnerable populations: We will include patients who are cognitively impaired due to hepatic encephalopathy and unable to consent for themselves.
Exclusion Criteria
- Patients < 18 years of age
- Patients who require outpatient physical therapy.
- Patients without the ability to consent for themselves or through a medical power of attorney.
Data sourced from ClinicalTrials.gov (NCT04836923). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.