Phase 2
Completed N=338
A Study of LY3437943 in Participants Who Have Obesity or Are Overweight
Source: ClinicalTrials.gov NCT04881760 ↗Enrolled (actual)
338
Serious AEs
3.9%
Results posted
Sep 2023
Primary outcomePrimary: Mean Percent Change From Baseline in Body Weight — -1.55; -7.18; -12.00; -13.80 percent change — p=<0.001
Summary
This is a study of LY3437943 in participants who have obesity or are overweight. The main purpose is to learn more about how LY3437943 affects body weight loss. The study will last about 18 months and may include up to 18 visits.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Percent Change From Baseline in Body Weight |
-2.11; -8.67; -16.32; -17.83; -21.72; -23.88 | <0.001 sig |
| SECONDARY Mean Percent Change From Baseline in Body Weight |
-2.11; -8.67; -16.32; -17.83; -21.72; -23.88 | <0.001 sig |
| SECONDARY Percentage of Participants Who Achieve ≥ 5% Body Weight Reduction |
27; 64; 87; 97; 100; 100 | <0.001 sig |
| SECONDARY Percentage of Participants Who Achieve ≥ 5% Body Weight Reduction |
27; 64; 87; 97; 100; 100 | <0.001 sig |
| SECONDARY Percentage of Participants Who Achieve ≥ 10% Body Weight Reduction |
9; 27; 73; 76; 90; 91 | 0.008 sig |
| SECONDARY Percentage of Participants Who Achieve ≥ 10% Body Weight Reduction |
9; 27; 73; 76; 90; 91 | 0.008 sig |
| SECONDARY Percentage of Participants Who Achieve ≥ 15% Body Weight Reduction |
2; 16; 55; 64; 73; 77 | 0.002 sig |
| SECONDARY Percentage of Participants Who Achieve ≥ 15% Body Weight Reduction |
2; 16; 55; 64; 73; 77 | 0.002 sig |
| SECONDARY Mean Change From Baseline in Body Weight |
-1.84; -9.37; -17.32; -19.13; -23.52; -25.88 | <0.001 sig |
| SECONDARY Mean Change From Baseline in Body Weight |
-1.84; -9.37; -17.32; -19.13; -23.52; -25.88 | <0.001 sig |
| SECONDARY Mean Change From Baseline in BMI |
-0.72; -3.22; -6.14; -6.67; -8.12; -9.02 | <0.001 sig |
| SECONDARY Mean Change From Baseline in BMI |
-0.72; -3.22; -6.14; -6.67; -8.12; -9.02 | <0.001 sig |
| SECONDARY Mean Change From Baseline in Waist Circumference |
-2.64; -6.49; -14.58; -14.87; -18.53; -18.50 | 0.010 sig |
| SECONDARY Mean Change From Baseline in Waist Circumference |
-2.64; -6.49; -14.58; -14.87; -18.53; -18.50 | 0.010 sig |
Eligibility Criteria
Inclusion Criteria
- Participants must have a Body Mass Index (BMI) ) ≥30 and ≤50 kilograms per square meter (kg/m²), or ≥27 kg/m² and more than 5 kg (11 pounds) within the past 3 months
- Participants must not have had surgery for obesity or plan to have such surgery during the study
- Participants must not be using medications that promote weight loss or cause weight gain
- Participants must not drink excessive amounts of alcohol (more than 14 units a week for women or more than 21 units a week for men)
- Participants must not have used marijuana within the last 3 months.
- Participants must not have heart attack, stroke, or hospitalization for congestive heart failure in the past 3 months
- Participants must not have active cancer within the last 5 years
- Participants must not have uncontrolled high blood pressure
- Participants must not have liver disease other than non-alcoholic fatty liver disease
- Participants must not have renal impairment with estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m2
- Participants must not have a history of acute or chronic pancreatitis symptomatic gallbladder disease or documented human immunodeficiency virus infection
- Participants must not have a major problem with depression or other mental illness within the last 2 years
- Participants must not have family or personal history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma (family is defined as a first degree relative)
- Female participants must not be pregnant, breast-feeding, or intend to become pregnant or of childbearing potential and not using adequate contraceptive method (adequate contraceptive measures as required by local regulation or practice)
Data sourced from ClinicalTrials.gov (NCT04881760). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.