N/A
N=115
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
Opioid Use · Opioid-use Disorder · Suicide
Bottom Line
View on ClinicalTrials.gov: NCT04939727 ↗Enrolled (actual)
115
Serious AEs
60.0%
Results posted
Aug 2023
Primary outcome: Primary: Number of Participants With CSSRS Completion on the Same Day or in the 14 Days Following Any Outpatient Visit — 14; 8 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- OUD-CDS + Suicide Risk Model associated CDS (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- HealthPartners Institute
- Primary completion
- Jul 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With CSSRS Completion on the Same Day or in the 14 Days Following Any Outpatient Visit |
14; 8 | — |
| PRIMARY Number of Outpatient Visits With Adequate Mental Health Engagement |
789; 489 | — |
| PRIMARY Number of Participants With One or More Suicide Attempts |
19; 15; 3; 0 | — |
| PRIMARY Number of Participants With One or More Opioid Overdoses |
8; 7; 2; 5 | — |
Summary
This study integrates the Mental Health Research Network (MHRN) suicide risk models into Opioid Wizard, an electronic health record (EHR) clinical decision support (CDS) to identify and treat patients at high risk of opioid use disorder (OUD)/overdose or diagnosed with OUD, to alert primary care clinicians (PCCs) to patients at elevated risk for suicide and guide them through structured suicide risk assessment. In both intervention and control clinics, suicide risk scores will be calculated for all Opioid Wizard-eligible patients and relevant EHR data to inform analyses will be archived. In intervention clinics, Opioid Wizard will alert PCCs to Opioid Wizard-eligible patients who are at increased risk of suicide and coach them through use of the Columbia Suicide Severity Risk Scale (CSSRS), a structured tool in the EHR that will help PCCs assess immediate suicide risk. Based on the resulting CSSRS score, Opioid Wizard will provide EHR links for risk-based referrals and follow-up recommendations, including care as usual, routine or emergent referral to behavioral health, or transportation to the emergency department (ED) for further assessment. Primary outcome measures include completion of CSSRS assessments for at-risk patients and patient engagement in outpatient mental health care.
Eligibility Criteria
Inclusion Criteria
- Be aged 18-75 years, inclusive, at the time of index visit
- Have an OUD diagnosis, be prescribed an active MOUD, or be identified by the opioid risk models as being at high risk of OUD or overdose
- Be identified at high risk of suicide by the suicide risk models
Exclusion Criteria
- Active parenteral chemotherapy within the last year
- Stage 4 or equivalent cancer diagnoses
- Enrolled in hospice or palliative care programs.
Data sourced from ClinicalTrials.gov (NCT04939727). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.