N/A
Completed N=60
Cognitive Reappraisal Training for Borderline Personality
Source: ClinicalTrials.gov NCT04967222 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcomePrimary: Change in PINES Network Activity — 0.15; 0.14; 0.12; 012 BOLD Signal
Summary
Previous work by the study group convinced the study team to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in PINES Network Activity |
0.15; 0.14; 0.12; 012 | — |
| PRIMARY Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD) |
15.22; 12.86; 10; 9.38 | — |
| SECONDARY Change in ZAN-BPD Sector Scores |
5.33; 5; 4; 2.71; 1.89; 2.57 | — |
| SECONDARY Change in Affective Lability Scale Total (ALS) |
95; 104; 82.91; 93.27; 74.3; 85.8 | — |
| SECONDARY Change in Perceived Stress Scale (PSS) |
2.28; 2.36; 2.19; 2.17; 2.22; 2.28 | — |
| SECONDARY Change in Difficulty in Emotion Regulation Scale Scores (DERS) |
119.15; 126.58; 109.09; 117.99; 110.2; 112.70 | — |
| SECONDARY Change in Beck Depression Scale Score (BDI) |
24.62; 20.08; 22.09; 15.36; 22.3; 16.3 | — |
| SECONDARY Change in State-Trait Anxiety Scale Score (STAXI) |
84.54; 90.5; 86.91; 87.36; 90.9; 91.5 | — |
Eligibility Criteria
Inclusion Criteria
- Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent.
- Subjects who are being treated with psychotherapy or psychopharmacotherapy will be included so long as there has been no change in that treatment over the preceding 2 months.
Exclusion Criteria
- Age > 55
- Criteria for Schizotypal Personality Disorder or Avoidant Personality Disorder. SPD is excluded to avoid possible confound from the restricted affect that characterizes SPD and co-morbid AvPD subjects will be excluded because the researchers have shown that their patterns of neural activity in emotion processing are distinct from BPD subjects.
Data sourced from ClinicalTrials.gov (NCT04967222). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.