N/A
N=30
Atrial Natriuretic Peptide in Assessing Fluid Status
Fluid Overload · Fluid Loss · Volume Overload · Cardiac Disease · Cardiac Output, Low
Bottom Line
View on ClinicalTrials.gov: NCT05070819 ↗Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Number of Patients With Pro-ANP Twofold Raise by the End of Surgery — 17 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- pro-ANP (Diagnostic_test)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Petrovsky National Research Centre of Surgery
- Primary completion
- Mar 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Patients With Pro-ANP Twofold Raise by the End of Surgery |
17 | — |
| PRIMARY Number of Patients With Pro-ANP Increase > 10% by the PLR Maneuver |
5 | — |
| PRIMARY Number of Patients With Cardiac Index Rise > 10% After Passive Leg Raising Maneuver |
5 | — |
| PRIMARY Number of Patients With Pro-ANP Increase > 10% by the PLR Maneuver at the End of Surgery |
8 | — |
| SECONDARY Postoperative Complications |
8 | — |
| SECONDARY Mortality |
— | — |
| SECONDARY Multiorgan Failure |
— | — |
| SECONDARY Respiratory Failure |
— | — |
| SECONDARY Renal Failure |
— | — |
| SECONDARY Heart Failure |
1 | — |
| SECONDARY Circulatory Insufficiency |
3 | — |
| SECONDARY Infection Rate |
— | — |
| SECONDARY Length of Intensive Care Stay |
22 | — |
Summary
Biomarkers can play a significant role in fluid status assessment intraoperatively.
Eligibility Criteria
Inclusion Criteria
CABG, one-, two valve repair/replacement, ascending aorta, aortic arch replacement, ASD/AVD closure, septal myectomy
Exclusion Criteria
- Atrial fibrillation, atrial flutter, frequent ventricular and supraventricular arrythmias
- EFLV 2 st
- CKD > C3 (GFR 150 ml
- LV EDV > 250 ml
Data sourced from ClinicalTrials.gov (NCT05070819). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.