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Home › Conditions › Fluid Loss

Fluid Loss

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Fluid Loss

7 trials tracked for Fluid Loss: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 28 citations.

7Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Other / NA 6
  1. Phase 4 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed · 28 cited
  2. N/A Evaluation of Physiological Variables and Detection of Blood Loss Using the Zynex Fluid Monitoring System, Model CM-1600 Completed
  3. N/A Clinical Evaluation of the Zynex Monitoring System, Model CM-1600 Completed
  4. N/A Clinical Evaluation of the CM-1500 During Apheresis Blood Donation Completed
  5. N/A Atrial Natriuretic Peptide in Assessing Fluid Status Completed
  6. N/A Clinical Evaluation of the CM-1500 During Hemodialysis Completed
Show 1 more trials
  1. N/A Evaluation of Physiological Variables and Detection of Blood Loss in Healthy Adults With Different Subject Positioning by the CM-1500 Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Fluid Loss: what the trials found

Clinical evaluation of Lactated Ringer Solution for fluid loss management shows that while Quality of Recovery-40 scores at 24 hours did not differ significantly between groups (p=0.608), there was a statistically significant improvement in Quality of Recovery-40 scores immediately following administration (p=0.027) 1. The number of participants filling an ED prescription showed no significant difference 1.

Evidence confirms the use of CM-1500 [4, 7] and CM-1600 [5, 6] as interventions in the context of fluid management.

Recent results — preliminary, needs further review

  • pro-ANP is currently being investigated but results are not yet corroborated 2.
  • Whole blood donation supine was studied regarding heart rate changes after minor blood loss (e.g., 500mL), showing a percent change of 10.7% and 14.7% respectively, though these findings are not yet corroborated 3.

For the clinician treating this condition

  • Lactated Ringer Solution is associated with statistically significant improvements in Quality of Recovery-40 scores immediately following administration 1.
  • CM-1500 and CM-1600 are established interventions for fluid loss management [4, 5, 6, 7].

AI synthesis of 3 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
FDA Approves Ringer's In Plastic Container (Ringer's solution) for parenteral replacement of extracellular fluid and electrolyte losses
Nephrology FDA Approval
FDA Approves Ringer's In Plastic Container (Ringer's solution) for parenteral replacement of extracellular fluid and electrolyte losses The FDA approved a new intravenous fluid called Ringer's In Plastic Container
The FDA approved Ringer's In Plastic Container for parenteral replacement of extracellular losses of fluid and electrolytes, as required by …
FDA approves new IV fluid to replace lost water and minerals like sodium and potassium for patients needing hydration after surgery or from …
FDA Mar 31, 2026