Phase 4 N=57 Loop Diuretics Administration and Acute Heart Failure
Acute Heart Failure
Primary: Evaluation of Mean Urine Output Volume During the Infusion Period — 2505; 2140 mL — p=0.04
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=82 Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
Septic Shock · Fluid Therapy · Hypotension
Primary: Cumulative Fluid Administered — 4417; 4110 mL of study fluid
N/A N=47 FAST (Fluid Accumulation Status Trial)
Congestive Heart Failure · Cardiomyopathy · Dyspnea
Primary: Number of Subjects With at Least 30 Days of Daily Impedance Measurements — 47; 106 participants
Phase 4 N=519 Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)
Acute Decompensated Heart Failure · Volume Overload
Primary: Successful Decongestion — 79; 108 Participants
Phase 2 N=30 Fluid Chloride and AKI in Cardiopulmonary Bypass
Acute Kidney Injury
Primary: Change in [TIMP2]*[IGFBP7] Biomarker — 0.015; 0.009 (ng/mL)^2/1000
N/A N=20 A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)
Acute Kidney Injury
Primary: Diagnostic Performance of the Net Ultrafiltration (UF NET) Challenge to Detect de Novo Preload Dependence — 0.74 Proportion probability (0 to 1) — p=0.02
Phase 3 N=45 Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial
Edema · Hypoproteinemia
Primary: Ventilator-free Days — 4; 13 days
Phase 4 N=170 Fluid Balance Study in Sick Neonates
Very Low Birth Weight Infant
Primary: Duration of Admission at the Ward in Days — 9; 8 number of days — p=<0.05
Phase 4 N=40 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
Hypotension · Kidney Injury
Primary: Development of Renal Injury — 0.8; 0.74 mg/dL — p=0.31
N/A N=30 A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study)
Sepsis
Primary: ICU-free Days to 14 Days After Enrollment — 9; 11 days
Phase 4 N=33 Aquaresis Utility for Hyponatremic Acute Heart Failure Study
Heart Failure
Primary: Median Urine Output at 24 Hours Post Randomization — 2910; 3150 mL
Phase 2 N=33 Hemodynamics and Extravascular Lung Water in Acute Lung Injury
Acute Lung Injury
Primary: The Primary Efficacy Variable Will be the Total Reduction in Measured Lung Water
N/A N=64 Fluid Management in Transient Tachypnea of the Newborn
Transient Tachypnea of the Newborn
Primary: Duration of Respiratory Support — 45; 42 hours
N/A N=14 Effects of Exercise Training on Fluid Instability in Heart Failure Patients
Heart Failure
Primary: Bioelectrical Impedance Change — 47.52; 47.1; 41.27; 46.8 Percentage of Extra Cellular Fluid
Phase 3 N=59 Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
Anesthesia
Primary: Change in Base Deficit — -1.5; -1.2; -0.5 mEq/L
Phase 2 N=81 Bolus of Saline in Stroke
Ischemic Stroke
Primary: The Percentage of Change in Optical Cerebral Blood Flow (oCBF) During Bolus Normal Saline Compared to Baseline, as Measured by Diffuse Correlation Spectroscopy (DCS)…
N/A N=68 Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
Intracranial Aneurysm · Brain Edema · Scoliosis
Primary: Number of ICU Stays Greater Than 1.5 Days — 13; 20 Number of ICU Stays greater that 1.5 Day
N/A N=30 LifeFlow Fluid Study- Non- Critical Pediatric Patients Having a Trans Abdominal Ultrasound
Dehydration in Children · Dehydration
Primary: Duration- Ultrasound Ordered to Completed — 154.4; 114.8 minutes
Phase 4 N=40 Tolvaptan For Worsening Outpatient Heart Failure: Role of Copeptin In Identifying Responders
Congestive Heart Failure
Primary: Change in Body Weight at 48 Hours — -3.3; -0.8 pounds — p=0.094
N/A N=150 Fluid Responsiveness Evaluation in Sepsis-associated Hypotension
Sepsis · Hypotension
Primary: Fluid Balance — 0.65; 2.02 Liters — p=0.021
N/A N=46 Restrictive Fluid Therapy in Severe Preeclampsia
Pre-Eclampsia
Primary: Renal Function in Severe Preeclampsia With Restrictive Fluid Therapy — 0.69; 0.73; 0.99; 0.93 mg/dl — p=<0.05
Early Phase 1 N=40 Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
Heart Failure
Primary: Change in Blood Volume — -320; -447 mL — p=0.56
Phase 4 N=48 Hyperosmolar Saline Irrigation Fluid in Arthroscopic Knee Surgery
Arthroscopic Knee Surgery
Primary: Fluid Extravasation — 1.8; 1.2 centimeters
Phase 3 N=20 A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)
Cardiac Edema
Primary: Body Weight — -1.68; -2.14 Kg
Phase 2 N=39 Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis
Chronic Kidney Disease Requiring Chronic Dialysis
Primary: Percentage of Participants Who Have a Defined Increase in 24-hour Urine Volume From Baseline to Week 5 — 33 percentage of participants
Phase 3 N=308 Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)
Heart Failure
Primary: Patient Well Being, as Determined by a Visual Analog Scale — 4236; 4372.7; 4170.8; 4429.6 units on a scale
N/A N=21 Lung Ultrasound in PD Patients
Peritoneal Dialysis · Hypervolemia · VEGF Overexpression
Primary: Association Between Number of Kerley B Lines by Ultrasound and Serum VEGF-C Level (pg/ml) by Enzyme-linked Immunosorbent Assay — 0.29; 0.25; 0.33 ng/ml — p=0.039
N/A N=974 Isotonic Solution Administration Logistical Testing
Acute Kidney Injury
Primary: Proportion of Isotonic Crystalloid Which is 0.9% Saline — 91.2; 21.0 Percentage of fluid that was saline — p=0.001
Phase 3 N=188 Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)
Heart Failure
Primary: Change in Serum Creatinine — -0.04; 0.23 mg/dL
N/A N=330 Assisted Fluid Management IDE Study
Non-Cardiac/ Non-Thoracic Surgery · Abdominal Surgery · Pelvic Surgery
Primary: Effectiveness of the Assisted Fluid Management Feature — 307 Participants