N/A
N=612
Interrupting HIV and TB Stigma in the Household in Uganda
Hiv · Tuberculosis · Social Behavior · Stigma, Social · Stigmatization
Bottom Line
View on ClinicalTrials.gov: NCT05124665 ↗Enrolled (actual)
612
Serious AEs
0.0%
Results posted
Feb 2024
Primary outcome: Primary: Proportion of Contacts Accepting HIV Testing — 279; 172 Participants — p=0.004
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Social Support (Behavioral)
- Age
- Pediatric, Adult, Older Adult · 15+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Jul 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Proportion of Contacts Accepting HIV Testing |
279; 172 | 0.004 sig |
| SECONDARY Change in Score of Perceived HIV Stigma |
2.57; -0.21 | 0.358 |
| SECONDARY Change in Score of Perceived TB Stigma |
0.47; -2.52 | 0.199 |
| SECONDARY Change in Effects of Perceived HIV Stigma on HIV Test Uptake |
2.59; -0.17 | 0.03 sig |
| SECONDARY Change in Effects of Perceived TB Stigma on HIV Test Uptake |
-0.46; -2.34 | 0.64 |
| SECONDARY Proportion of Index Patient Nominated Household Members Who Accept HIV Test |
58; 33 | 0.452 |
| SECONDARY Number of Social Support Household Contacts Deciding to Test for HIV |
196 | 0.264 |
Summary
The investigators will carry out a prospective, household cluster-randomized, implementation trial evaluating a complex, multi-component, social and behavioral intervention designed to normalize the acceptance of HIV testing in the household and increase diagnosis of HIV.
Eligibility Criteria
Index Patient and Household Eligibility:
- Index patient is eligible for contact investigation (TB patient of any age identified in the facility's National TB and Leprosy Programme (NTLP) TB Treatment Register as initiating treatment or returning for 2-week follow-up)
- Index patient or legal guardian agrees to study procedures in addition to routine contact investigation
- Index patient has at least 2 self-reported household contacts age 15 or above
- Household is within the boundaries of the Kampala Capital City Authority, Uganda
- Does not have multi-drug resistant (MDR) TB
Contact Participant Eligibility:
- Household contact age ≥15 years
- Agrees to study procedures in addition to routine contact investigation
Data sourced from ClinicalTrials.gov (NCT05124665). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.