N/A
N=49
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
Opioid Misuse · Chronic Pain
Bottom Line
View on ClinicalTrials.gov: NCT05182606 ↗Enrolled (actual)
49
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Feasibility of Algorithms — 7; 13 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Pilot study of algorithms implementation package (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Pittsburgh
- Primary completion
- Sep 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Feasibility of Algorithms |
7; 13 | — |
| PRIMARY Acceptability of Algorithms |
19; 7 | — |
| SECONDARY Preliminary Effectiveness of Algorithms - MME Reduction ≥10% |
297; 122; 270 | — |
| SECONDARY Preliminary Effectiveness - Average MME Within Last 90 Days |
105.25; 96.76; 96.48 | — |
| SECONDARY Preliminary Effectiveness of Algorithms - Opioid Discontinuation |
95; 109; 166 | — |
| SECONDARY Preliminary Effectiveness of the Algorithms - New OUD Diagnoses |
0; 0; 0 | — |
Summary
The NIH Helping to End Addiction Long-term (HEAL) initiative has identified a critical next step to addressing the opioid crisis: improving treatments for opioid misuse behaviors (e.g., using more opioids than prescribed, illicit substance use) in patients prescribed long-term opioid therapy for chronic pain. In previous work, the investigators have developed innovative consensus-based algorithms to manage these behaviors. By developing implementation strategies for these algorithms, this project is directly responsive to the HEAL initiative and promises to reduce opioid misuse-related harms.
Eligibility Criteria
Inclusion Criteria
- Clinicians practicing at UPMC community primary care clinics.
Exclusion Criteria
- Clinicians not practicing at UPMC community primary care clinics.
Data sourced from ClinicalTrials.gov (NCT05182606). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.