N/A N=49 Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
Opioid Misuse · Chronic Pain
Primary: Feasibility of Algorithms — 7; 13 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=190 Opioid Prescribing After Cesarean Delivery
Surgery · Opioid Use
Primary: Unused Opioids — 5; 10 oxycodone 5mg tablets
N/A N=533 A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
Opioid Misuse
Primary: Percentage Reporting 'Great Perceived Risk of Harm' From Opioid Misuse — 66; 53 Participants
Phase 2 N=16 A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.
Opioid Use Disorder
Primary: Positive Subjective Drug Effects (i.e., Drug "Liking"). — 52.1; 57.5; 71.8; 71.5 units on a scale — p=.0001
N/A N=204 Safety & Prevention Outcomes Study
Drug Overdose · Opioid-Related Disorders
Primary: Overdose Risk Behavior — -1.54; -0.51 Scores on a scale
N/A N=115 Opioid Treatment and Recovery Through a Safe Pain Management Program
Depression · Opioid Use · Chronic Pain
Primary: Odds of Morphine Equivalent Daily Dose (MEDD) of Opioid Prescription >=50 mg — 0.209; 0.417; 0.185; 0.364 odds of prescription high dose — p=0.956
Phase 2 N=51 Prescription Opioid Abuse Among Pain Patients: Predictors of Relapse
Opioid Dependence
Primary: Number of Participants Retained in Study — 18 participants
N/A N=286 Guiding Aging Long-Term Opioid Therapy Users Into Safer Use Patterns
Pain · Opioid Use
Primary: Count of Referrals to Non-opioid Care — 3.075; 3.61 Count of referrals — p=0.213
N/A N=299 Primary Care Intervention to Reduce Prescription Opioid Overdoses
Pain · Drug Overdose · Opioid Use Disorders
Primary: Overdose Risk Behaviors — 1.31; 1.21; 1.45; 1.25 score on a scale
N/A N=112 Co-Use of Opioid Medications and Alcohol Prevention Study
Alcohol Drinking · Opioid Use
Primary: Alcohol Use Reductions — 11; 12; 1; 1 Participants
N/A N=10 Empower Opioid Misuse & Chronic Pain
Chronic Pain · Opioid Use
Primary: Pain Intensity Score Measures — 55; 57 Score on a scale
N/A N=196 Discharge Opioid Education to Decrease Opioid Use After Cesarean
Opioid Use
Primary: Opioid Use — 7.5; 10 hydrocodone tablets
N/A N=111 Opiate Prescribing Guidelines Following Hip Arthroscopy
Hip Injuries
Primary: Numeric Pain Rating Scale (NPRS) Pain Scores — 4.2; 4.0 score on a scale
N/A N=127 Post-op Crowd Sourcing Health Data Via Text-messaging
Orthopedic Surgery · Opioid Use · Acute Injuries Knee
Primary: Number of Opioid Tablets Taken Within 28 Days — 8.05; 11.55 number of pills taken
N/A N=76 Evaluation of a Computerized Opioid Overdose Prevention Program
Computer + Fluency · Computer Only · Treatment as Usual
Primary: Knowledge Gain — 30.6; 30.5; 27.56; 40.7 units on a scale
N/A N=35 Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse
Chronic Pain · Problematic Opioid Use
Primary: Patient Reported Outcomes Measurement Information System (PROMIS) - Pain Behavior — 66.7; 66.0; 64.3; 66.8 units on a scale
N/A N=102 Optimizing Pregnancy and Treatment Interventions for Moms 2.0
Pregnancy, High Risk · Opioid-Related Disorders · Pregnancy Related
Primary: Opioid Use Disorder (OUD) and Other Substance Use Disorder (SUD) Treatment Linkage/Retention — -1.5; -8.8 Percentage of days
Phase 2 N=27 Prescription Opioid Effects in Abusers Versus Non-Abusers
Opioid-Related Disorders · Substance-Related Disorders
Primary: Breakpoint — 25; 400; 1400; 850 Mouse Clicks
Phase 4 N=319 Increasing Naloxone Access for Persons Who Use Opioids
Naloxone
Primary: The Number of Participants That Completed the Training in 6 Months — 55; 56; 10; 9 Participants
N/A N=503 Scenario Tailored Opioid Messaging Program (STOMP) to Improve Risk Understanding in Young Adults
Pain, Postoperative · Medication Adherence · Opioid Use
Primary: Opioid Risk Perception — 31.4; 31.1; 32.8; 30.02 score on a scale — p=.001
N/A N=321 Subthreshold Opioid Use Disorder Prevention (STOP) Trial
Opioid-use Disorder
Primary: Days of Risky Opioid Use in Past 180 Days — 12.2; 15.5 days
N/A N=851 Behavioral Insights to Encourage Judicious Prescribing of Opioids
Substance-Related Disorders
Primary: Average Change Over Time in Dispensed Narcotics — 347.65; 350.09; 288.36; 318.60 Morphine milligram equivalents — p=<0.05
Phase 2 N=80 Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)
Pain Management
Primary: Pain Reduction at 60 Minutes (Baseline Pain Score - Pain Score at 60 Minutes) — 3.95; 3.95 units on a scale
Phase 2 N=120 Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Surgery
Primary: Number of Oxycodone Tablets Used Day 1 — 1.0; 1.0 Oxycodone Tablets — p=.87
N/A N=55 Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
Opioid-use Disorder
Primary: Intervention PCP Confidence in Assessing and Treating OUD — 6; 11; 8; 1 Participants
Phase 4 N=12 A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine
Chronic Pain
Primary: 3 Scores on the Addiction Research Center Inventory (ARCI) — 7.6; 5.4; 5.2; 3.3 scores on a scale
N/A N=395 Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder
Opiate Antagonist Overdose · Opioid-Related Disorders
Primary: To Measure the Association of Take-home Naloxone With Overdose Reversals Performed by Patients With Opioid Use Disorder Enrolled in an Opioid Treatment Program — 73; 263…
Phase 4 N=160 Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty
Joint Disease · Pain, Acute · Pain, Chronic
Primary: Opioid Use — 288; 432.5 Oral Morphine Equivalent (mg)
N/A N=16 Usability Testing for the Reward-based Technology to Improve OUD Treatment
Opioid-use Disorder · Contingency Management · Medication for Opioid-use Disorder
Primary: OARSCM Usability - Phase 1 Usability — 12 Participants
N/A N=712 Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
Pain, Postoperative · Medication Adherence · Opioid Use
Primary: Opioid-related Risk Knowledge — 287; 289 Participants