N/A
N=202
Impact of a Corrie Cardiac Rehabilitation Program
Coronary Artery Disease · Myocardial Infarction · Myocardial Ischemia · Coronary Artery Occlusion · Coronary Artery Stenosis Stent
Bottom Line
View on ClinicalTrials.gov: NCT05238103 ↗Enrolled (actual)
202
Serious AEs
5.5%
Results posted
Dec 2025
Primary outcome: Primary: 6-minute Walking Distance (Meters) — 506.1; 489.8 meters — p=0.04
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Corrie Hybrid Cardiac Rehabilitation Program (Combination_product)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Oct 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY 6-minute Walking Distance (Meters) |
506.1; 489.8 | 0.04 sig |
| SECONDARY Composite Cardiovascular Health Metric for Secondary Prevention |
9.6; 9.5 | 0.58 |
| SECONDARY Blood Pressure (mmHg) |
122.7; 121.0; 70.5; 68.6 | 0.40 |
| SECONDARY Low Density Lipoprotein - Cholesterol (LDL-C) |
65.6; 71.4 | 0.27 |
| SECONDARY Glycosylated Hemoglobin (HbA1c) |
5.8; 5.9 | 0.39 |
| SECONDARY Body Mass Index (kg/m^2) |
30.2; 28.7 | 0.19 |
| SECONDARY Quality of Life as Assessed by the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health-10 |
50.4; 52.0; 52.0; 52.1 | 0.16 |
| SECONDARY Blood Pressure Control |
59; 65; 34; 27; 8; 9 | 0.60 |
| SECONDARY Cholesterol (LDL-C) Control |
62; 52; 23; 30; 16; 19 | 0.57 |
| SECONDARY Diabetes Control |
66; 55; 32; 40; 3; 6 | 0.28 |
| SECONDARY Weight (BMI) Categories |
25; 29; 23; 35; 53; 37 | 0.09 |
| SECONDARY Physical Activity Categories |
72; 81; 29; 18; 0; 2 | 0.19 |
| SECONDARY Diet Categories |
62; 57; 39; 44; 0; 0 | 0.60 |
| SECONDARY Tobacco Use |
99; 89; 2; 12 | 1.00 |
| SECONDARY Cardiac Rehabilitation Engagement |
37; 31; 20; 29; 44; 41 | 0.35 |
Summary
In this randomized clinical trial, the researchers are investigating whether a multi-component virtual/hybrid cardiac rehabilitation program will improve functional status, cholesterol level, overall cardiovascular health, individual risk factors, quality of life and mental health for patients who have recently been diagnosed with myocardial infarction, received a coronary stent, underwent heart surgery or catheter-based valve replacement, as compared to traditional, center-based cardiac rehabilitation.
Eligibility Criteria
Inclusion Criteria
- 18 years or older
- Individuals admitted to the hospital for the following conditions or interventions during the index admission: Acute myocardial infarction (STEMI or NSTEMI type 1), Coronary artery bypass grafting (CABG), and Coronary artery angioplasty/stenting (PCI), Heart valve surgery, catheter-based aortic valve replacement (TAVR).
Exclusion Criteria
- Non-English speaking
- Symptomatic severe aortic stenosis or other severe valvular disease
- Physical disability that would preclude safe and adequate exercise performance
- Hypertrophic obstructive cardiomyopathy with peak resting left ventricular outflow gradient of >25 mmHg
- Known aortic dissection
- Severe resting arterial hypertension (Systolic blood pressure >200 mmHg or diastolic BP >110mmHg) at baseline assessment
- Mental impairment leading to inability to cooperate with study procedures
- Untreated high degree atrioventricular block
- Atrial fibrillation with uncontrolled ventricular rate (Heart rate >110 at rest) at baseline assessment
- History of cardiac arrest or sudden death
- Myocardial infarction or cardiac surgery complications with cardiogenic shock and/or congestive heart failure and/or signs/symptoms of post-procedure ischemia
- Left ventricular ejection fraction <40%
- History of Clinically significant depression
- Visual or hearing impairment which precludes the use of the intervention
- Presence of cardiac defibrillator
- Incomplete revascularization procedure
- History of one or more episodes of falls in the last year
- Pregnancy
- If patients are deemed clinically unstable and unable to participate at the time of initial screening, the research team member may return at a later date to determine whether this status has changed.
Data sourced from ClinicalTrials.gov (NCT05238103). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.