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N/A N=202 Randomized Single-blind Supportive Care

Impact of a Corrie Cardiac Rehabilitation Program

Coronary Artery Disease · Myocardial Infarction · Myocardial Ischemia · Coronary Artery Occlusion · Coronary Artery Stenosis Stent

Enrolled (actual)
202
Serious AEs
5.5%
Results posted
Dec 2025
Primary outcome: Primary: 6-minute Walking Distance (Meters) — 506.1; 489.8 meters — p=0.04

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Corrie Hybrid Cardiac Rehabilitation Program (Combination_product)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Johns Hopkins University
Primary completion
Oct 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
6-minute Walking Distance (Meters)
506.1; 489.8 0.04 sig
SECONDARY
Composite Cardiovascular Health Metric for Secondary Prevention
9.6; 9.5 0.58
SECONDARY
Blood Pressure (mmHg)
122.7; 121.0; 70.5; 68.6 0.40
SECONDARY
Low Density Lipoprotein - Cholesterol (LDL-C)
65.6; 71.4 0.27
SECONDARY
Glycosylated Hemoglobin (HbA1c)
5.8; 5.9 0.39
SECONDARY
Body Mass Index (kg/m^2)
30.2; 28.7 0.19
SECONDARY
Quality of Life as Assessed by the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health-10
50.4; 52.0; 52.0; 52.1 0.16
SECONDARY
Blood Pressure Control
59; 65; 34; 27; 8; 9 0.60
SECONDARY
Cholesterol (LDL-C) Control
62; 52; 23; 30; 16; 19 0.57
SECONDARY
Diabetes Control
66; 55; 32; 40; 3; 6 0.28
SECONDARY
Weight (BMI) Categories
25; 29; 23; 35; 53; 37 0.09
SECONDARY
Physical Activity Categories
72; 81; 29; 18; 0; 2 0.19
SECONDARY
Diet Categories
62; 57; 39; 44; 0; 0 0.60
SECONDARY
Tobacco Use
99; 89; 2; 12 1.00
SECONDARY
Cardiac Rehabilitation Engagement
37; 31; 20; 29; 44; 41 0.35

Summary

In this randomized clinical trial, the researchers are investigating whether a multi-component virtual/hybrid cardiac rehabilitation program will improve functional status, cholesterol level, overall cardiovascular health, individual risk factors, quality of life and mental health for patients who have recently been diagnosed with myocardial infarction, received a coronary stent, underwent heart surgery or catheter-based valve replacement, as compared to traditional, center-based cardiac rehabilitation.

Eligibility Criteria

Inclusion Criteria

  • 18 years or older
  • Individuals admitted to the hospital for the following conditions or interventions during the index admission: Acute myocardial infarction (STEMI or NSTEMI type 1), Coronary artery bypass grafting (CABG), and Coronary artery angioplasty/stenting (PCI), Heart valve surgery, catheter-based aortic valve replacement (TAVR).

Exclusion Criteria

  • Non-English speaking
  • Symptomatic severe aortic stenosis or other severe valvular disease
  • Physical disability that would preclude safe and adequate exercise performance
  • Hypertrophic obstructive cardiomyopathy with peak resting left ventricular outflow gradient of >25 mmHg
  • Known aortic dissection
  • Severe resting arterial hypertension (Systolic blood pressure >200 mmHg or diastolic BP >110mmHg) at baseline assessment
  • Mental impairment leading to inability to cooperate with study procedures
  • Untreated high degree atrioventricular block
  • Atrial fibrillation with uncontrolled ventricular rate (Heart rate >110 at rest) at baseline assessment
  • History of cardiac arrest or sudden death
  • Myocardial infarction or cardiac surgery complications with cardiogenic shock and/or congestive heart failure and/or signs/symptoms of post-procedure ischemia
  • Left ventricular ejection fraction <40%
  • History of Clinically significant depression
  • Visual or hearing impairment which precludes the use of the intervention
  • Presence of cardiac defibrillator
  • Incomplete revascularization procedure
  • History of one or more episodes of falls in the last year
  • Pregnancy
  • If patients are deemed clinically unstable and unable to participate at the time of initial screening, the research team member may return at a later date to determine whether this status has changed.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05238103). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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