N/A
Completed N=25
Optimizing Cerebral Autoregulation During Surgery
Hip Fracture · Hip Arthropathy · Surgery · Delirium
Source: ClinicalTrials.gov NCT05308290 ↗
Enrolled (actual)
25
Serious AEs
44.0%
Results posted
Jul 2025
Primary outcomePrimary: Mean Arterial Pressure Outside Limits of Cerebral Autoregulation — 2.2; 1.8 mmHg * hours — p=0.60
Summary
The purpose of this study is to conduct a pilot trial to determine the feasibility, safety, and potential efficacy of targeting mean arterial blood pressure (MAP) within the limits of cerebral autoregulation during surgery compared with usual care.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Arterial Pressure Outside Limits of Cerebral Autoregulation |
2.2; 1.8 | 0.60 |
| PRIMARY Estimated Blood Loss |
17.5; 12.9 | 0.60 |
| PRIMARY Number of Participants With New Myocardial Infarction After Surgery |
0; 0 | 1.0 |
| PRIMARY Number of Participants With New Stroke After Surgery |
0; 0 | 1.0 |
| SECONDARY Number of Participants That Develop Delirium After Surgery |
0; 1 | 0.28 |
| SECONDARY Change in General Cognitive Function as Assessed by the Short Blessed Test |
— | — |
| SECONDARY Change in Executive Cognitive Function as Assessed by the Oral Trail Making Test |
— | — |
| SECONDARY Dementia Screening as Assessed by the AD8 Test |
— | — |
| SECONDARY Change in General Overall Health and Disability as Assessed by the WHO Disability Assessment Schedule 2.0 |
— | — |
| SECONDARY Change in General Function as Assessed by the Instrumental Activities of Daily Living Questionnaire |
— | — |
| SECONDARY Change in Ability to Ambulate Without Human Assistance |
— | — |
Eligibility Criteria
Inclusion Criteria
- planned hip or knee surgery (either for fracture or elective) or lung surgery
- age ≥60
- ambulatory at baseline
- expected duration of surgery > 90 minutes
Exclusion Criteria
- Planned concurrent surgery
- Allergy to adhesive tape
- Short Blessed Test score >20
- Clinical diagnosis of dementia
- Opinion of either the anesthesiologist or surgeon that the patient is not appropriate.
Data sourced from ClinicalTrials.gov (NCT05308290). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.