N/A
N=51
Cognitive Behavioral Suicide Prevention for Psychosis: Aim 2
Suicide · Psychosis
Bottom Line
View on ClinicalTrials.gov: NCT05345184 ↗Enrolled (actual)
51
Serious AEs
13.7%
Results posted
Mar 2026
Primary outcome: Primary: Calgary Depression Rating Scale (CDRS) — 18.20; 17.15; 16.09; 15.39 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) (Behavioral); Services as Usual (SAU) (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Michigan
- Primary completion
- May 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Calgary Depression Rating Scale (CDRS) |
18.20; 17.15; 16.09; 15.39; 13.95; 15.83 | — |
| PRIMARY Positive and Negative Syndrome Scale (PANSS) |
82.72; 75.27; 77.68; 71.69; 71.57; 76.96 | — |
| PRIMARY Columbia Suicide Severity Rating Scale (C-SSRS) |
2.52; 1.77; 1.45; 1.48; 1.09; 1.52 | — |
| SECONDARY Beck Hopelessness Scale |
7.04; 7.85; 5.67; 7.0; 4.0; 7.26 | — |
| SECONDARY Defeat Scale (D Scale) |
31.24; 32.19; 27.57; 28.52; 22.71; 27.61 | — |
| SECONDARY The Entrapment Scale |
28.12; 22.04; 27.62; 23.83; 18.33; 27.14 | — |
Summary
Investigators will evaluate the feasibility and preliminary effectiveness of modified Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) in comparison to services-as-usual (SAU) in a randomized controlled trial. Investigators will recruit adult clients receiving services at a community mental health (CMH) setting who have a schizophrenia spectrum disorder and recent suicidal thoughts or behaviors within 3 months of screening (n=60). Client participants will be screened, enrolled and randomized to the CBSPp or SAU group. A 4-wave design will include quantitative assessments at baseline (T1), 1-month after baseline (T2), 3-months after baseline (T3), and 5-months after baseline (T4) with in-depth qualitative interviews at T3 for a random sample of adults in the CBSPp group (n=10). Providers (n=12) will be trained to deliver CBSPp and be assessed from T1-T3 to evaluate the implementation process, including in-depth qualitative interviews at T3.
Eligibility Criteria
Inclusion Criteria
- Schizophrenia Spectrum Disorder
- Suicide ideation and/or attempt within 3 months of screening
- Ability to speak and read in English
- 18 to 65 years of age
Exclusion Criteria
- Requiring emergency care (e.g. imminent plan to harm self) as determined by trained research staff administering the Columbia-Suicide Severity Rating Scale (C-SSRS)
- Inappropriate for behavioral treatment according to own judgment in consultation with a treating clinician CMH
- Impaired capacity (cognitive capacity)
Data sourced from ClinicalTrials.gov (NCT05345184). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.