N/A
N=16
Neural Underpinnings of Turning
Aging
Bottom Line
View on ClinicalTrials.gov: NCT05475236 ↗Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Duration of Cortical Silent Period (CSP) (ms) — 104.34; 99.71 milliseconds (ms)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Experimental: Locomotor Learning (Behavioral)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jun 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Duration of Cortical Silent Period (CSP) (ms) |
104.34; 99.71 | — |
| PRIMARY 360 Degree Turn Duration From Baseline |
0.306; .367 | — |
| PRIMARY 180 Degree Turn Duration From Baseline |
0.11; 0.22 | — |
| PRIMARY Resting Motor Threshold (Percent of Machine Output) |
56.13; 68.25 | — |
| SECONDARY Katz Independence Questionnaire |
6; 6 | — |
Summary
Older adults and stroke survivors often have difficulty performing complex walking tasks, due in part to changes in the brain. One task often overlooked is turning, which can lead to injury when performed poorly. The investigators will use non-invasive brain stimulation to assess brain activity and relate those observations to turning performance in older adults and stroke survivors.
Eligibility Criteria
Inclusion Criteria
- age 65 years or older
- preferred 10m walking speed 35)
- current cardiovascular, lung or renal disease; diabetes; terminal illness
- myocardial infarction or major heart surgery in the previous year
- cancer treatment in the past year, except for nonmelanoma skin cancers and cancers having an excellent prognosis (e.g., early stage breast or prostate cancer)
- current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder
- uncontrolled hypertension at rest (systolic > 180 mmHg and/or diastolic > 100 mmHg)
- bone fracture or joint replacement in the previous six months
- current participation in physical therapy for lower extremity function or cardiopulmonary rehabilitation
- current enrollment in any clinical trial
- difficulty communicating with study personnel, and/or non-English speaking
- planning to relocate out of the area during the study period
- clinical judgment of investigative team regarding safety or non-compliance
Data sourced from ClinicalTrials.gov (NCT05475236). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.