N/A
N=95
Adolescent Depression Screening and Treatment in Mozambican Primary Care
Depression · Adolescent Behavior
Bottom Line
View on ClinicalTrials.gov: NCT05476237 ↗Enrolled (actual)
95
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcome: Primary: Change in PHQ-A Score From Baseline to 6 Months Post-intervention — -35.9; -54.0 percent change
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Group Interpersonal Therapy for Adolescents (IPT-AG) (Behavioral); Treatment as Usual (TAU) (Behavioral)
- Age
- Pediatric, Adult, Older Adult · 12+ yrs
- Sex
- All
- Sponsor
- Columbia University
- Primary completion
- May 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in PHQ-A Score From Baseline to 6 Months Post-intervention |
-35.9; -54.0 | — |
| PRIMARY IPT-AG Fidelity |
1.3 | — |
Summary
This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province. YFHS will be stratified by urbanicity, such that one YFHS in Maputo City and one YFHS in Maputo Province will be randomized to interpersonal psychotherapy (IPT)-A and the other YFHS in each location with be randomized to treatment as usual (TAU).
Eligibility Criteria
Inclusion Criteria
- Providers:
- IPT-AG Arm: YFHS staff will be included in the study if they (a) conduct screening for depression and/or group IPT-AG and (b) provide consent to participate in the study.
- TAU Arm: YFHS staff will be included in the study if they (a) provide referrals for adolescents suspected of having mental illness or seeking mental health services and (b) provide consent to participate in the study. Treatment providers (Psychiatric Technicians and psychologists) will be included in the study if they (a) treat adolescents referred from participating YFHS for depression and (b) provide consent to participate in the study.
- Patients: In both study arms, adolescents attending one of the four study YFHS will be included in the study if they:
- are between the ages of 12-19 years;
- screen positive for depression;
- provide informed consent (ages 16 -19) or if their guardian provides informed consent and they provide assent (if ages 12-15).
- Study centers: must be clinics that have YFHS.
Exclusion Criteria
In both study arms, adolescents will be excluded if they:
- are unable to participate in treatment due to acute illness; and/or
- are unable to communicate sufficiently in Portuguese to answer inclusion questions.
Data sourced from ClinicalTrials.gov (NCT05476237). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.