N/A N=20 Randomized Triple-blind Treatment

Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults

Fatigue · Aging

Bottom Line

View on ClinicalTrials.gov: NCT05484661 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2024

Primary outcome: Primary: Fatigue — -5.6; -4.1 change in fatigue severity score

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: BCAA (Dietary_supplement)
Age: Adult, Older Adult · 60+ yrs
Sex: All
Sponsor: The University of Texas Health Science Center at San Antonio
Primary completion: Nov 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Fatigue	-5.6; -4.1	—

Summary

Fatigue is a strong predictor of negative health outcomes in older adults. The research in this study will compared the effects of 8-weeks of branched chain amino acids (BCAAs: dietary supplements commonly taken to improve muscle growth and exercise performance) added to exercise on fatigue compared to exercise with a placebo (an inactive, harmless substance). BCAAs could have an impact on improving fatigue common in older adults, especially when exercising.

Eligibility Criteria

Inclusion Criteria

Fatigue (participants reporting ≥3 on a 1-10 scale)
Lack of menses for at least one year for women
BMI 20-50 kg/m2
Untrained with regard to structured exercise training (is not currently training more than 2x/week)

Exclusion Criteria

Taking an anticoagulant medication that is unable to be discontinued before biopsies
Allergic to lidocaine
Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments or training
Hepatic (LFTs >2.5xWNL), renal (eGFR<45), , and uncontrolled psychiatric disease
Cognitive impairment
Uncontrolled depression
Any disease or condition considered to be exclusionary based on the clinical opinion and discretion of the principal investigator

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05484661). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.