N/A
Completed N=20
Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults
Source: ClinicalTrials.gov NCT05484661 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Nov 2024
Primary outcomePrimary: Fatigue — -5.6; -4.1 change in fatigue severity score
Summary
Fatigue is a strong predictor of negative health outcomes in older adults. The research in this study will compared the effects of 8-weeks of branched chain amino acids (BCAAs: dietary supplements commonly taken to improve muscle growth and exercise performance) added to exercise on fatigue compared to exercise with a placebo (an inactive, harmless substance). BCAAs could have an impact on improving fatigue common in older adults, especially when exercising.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Fatigue |
-5.6; -4.1 | — |
Eligibility Criteria
Inclusion Criteria
- Fatigue (participants reporting ≥3 on a 1-10 scale)
- Lack of menses for at least one year for women
- BMI 20-50 kg/m2
- Untrained with regard to structured exercise training (is not currently training more than 2x/week)
Exclusion Criteria
- Taking an anticoagulant medication that is unable to be discontinued before biopsies
- Allergic to lidocaine
- Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments or training
- Hepatic (LFTs >2.5xWNL), renal (eGFR<45), , and uncontrolled psychiatric disease
- Cognitive impairment
- Uncontrolled depression
- Any disease or condition considered to be exclusionary based on the clinical opinion and discretion of the principal investigator
Data sourced from ClinicalTrials.gov (NCT05484661). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.