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N/A Completed N=105 Randomized Double-blind Treatment

Behavioral Activation and Medication Optimization In Older Adults Undergoing Cardiac Procedures

Cardiac surgery · Older Adults · Depression · Anxiety
Source: ClinicalTrials.gov NCT05575128 ↗
Enrolled (actual)
105
Serious AEs
0.0%
Results posted
Apr 2026
Primary outcomePrimary: PHQ-ADS — 18.39; 18.59; 12.33; 11.67 Points

Summary

This Hybrid 1 Study will test the effectiveness of a bundled intervention comprised of behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing cardiac surgery (compared with usual care), while examining implementation outcomes.

Outcome Measures

OutcomeResultp-value
PRIMARY
PHQ-ADS
18.39; 18.59; 12.33; 11.67; 9.72; 12.60

Eligibility Criteria

Inclusion criteria

  • Adults ≥ 60 years
  • Scheduled major cardiac procedure
  • PHQ-ADS ≥ 10, indicating clinically significant depression or anxiety symptoms

Exclusion criteria

  • Barrier to communication (Unable to read, speak, and understand English)
  • Severe cognitive impairment screened by the SBT (Short Blessed Test) >10
  • Acutely suicidal
  • Previous participation in this study or CPMH feasibility study 202101103.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05575128). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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