N/A
N=309
Outreach to Reduce Depression Disparities
Depression
Bottom Line
View on ClinicalTrials.gov: NCT05580406 ↗Enrolled (actual)
309
Serious AEs
0.0%
Results posted
May 2026
Primary outcome: Primary: Number of Participants With Initiation of Formal Depression Treatment — 9; 36 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Outreach messaging (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Kaiser Permanente
- Primary completion
- Dec 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Initiation of Formal Depression Treatment |
9; 36 | — |
Summary
Previous research by Mental Health Research Network (MHRN) investigators and others demonstrates that online messaging and other telehealth technologies can effectively and efficiently address premature discontinuation of depression treatment. These interventions, however, have focused on adherence after treatment initiation and have been tested primarily in non-Hispanic white populations. Less is known about the acceptability and effectiveness of different communication modalities (online messaging, mailed letters, telephone) among racial and ethnic minority populations. Implementation of electronic-Health (eHealth) technologies must take care not to exacerbate health disparities.
This clinical trial involves a pilot trial to evaluate a population-based outreach program to improve rates of depression treatment initiation among traditionally underserved racial and ethnic groups. This pilot work intends to inform a subsequent full-scale pragmatic trial to examine impact on health disparities.
Eligibility Criteria
Inclusion Criteria
- New diagnosis of major depressive disorder or dysthymic disorder at a primary care visit ("new" defined as no depression diagnosis, psychotherapy visit or filled antidepressant prescription in the prior year)
- Continuously enrolled in the participating health system for 365 days prior to the eligible diagnosis (to assure capture of prior diagnoses or treatments)
- Patients Health Questionnaire-9 (PHQ-9) depression score of 10 or more within 14 days before to 7 days after the eligible diagnosis
- No filled prescription for any antidepressant medication OR psychotherapy visit attended within 30 days of the eligible diagnosis*
- No recorded PHQ-9 depression score less than 5 since the eligible diagnosis
- At least 18 years of age or older
Exclusion Criteria
- Diagnosis of schizophrenia or bipolar disorder in the prior 2 years
- Not registered to use Electronic Health Record (EHR) patient portal
- Previously requested to not be contacted for research
Data sourced from ClinicalTrials.gov (NCT05580406). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.