N/A
N=105
Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing Oncologic Surgery
Older Adults · Anxiety · Depression · Major Surgical Resection of a Thoracic Malignancy · Major Surgical Resection of an Abdominal Malignancy
Bottom Line
View on ClinicalTrials.gov: NCT05685511 ↗Enrolled (actual)
105
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcome: Primary: PHQ-ADS — 18.35; 16.67; 17.51; 10.95 points
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Behavioral Activation (Behavioral); Medication Optimization (Other); Usual care resources (Other)
- Age
- Adult, Older Adult · 60+ yrs
- Sex
- All
- Sponsor
- Washington University School of Medicine
- Primary completion
- Jul 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PHQ-ADS |
18.35; 16.67; 17.51; 10.95; 12.52; 11.74 | — |
Summary
Using a Hybrid Type 1 Effectiveness-Implementation randomized control trial (RCT) design, the investigators will test the effectiveness of a bundled behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing oncologic surgery (compared with usual care), while examining implementation outcomes.
Eligibility Criteria
Inclusion Criteria
Pre-screening:
To be considered for participation, patients will be screened using PHQ-4 questionnaire. Scores >3 will indicate positive pre-screen (i.e. can be considered for participation and formal screening). Scores 10
- Acutely suicidal
- Considered ineligible per the discretion of the oncologic surgeon or study PI
- Previous participation in this study or another CPMH study of the intervention bundle or its feasibility.
Data sourced from ClinicalTrials.gov (NCT05685511). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.