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N/A N=165 Randomized Single-blind Treatment

Brain Health Together: A Live-Streaming Group-Based Digital Program

Mild Cognitive Impairment · Cognitive Decline · Cognitive Deterioration · Cognitive Deficits, Mild · Cognitive Impairment, Mild

Bottom Line

View on ClinicalTrials.gov: NCT05818423 ↗
Enrolled (actual)
165
Serious AEs
4.9%
Results posted
Apr 2026
Primary outcome: Primary: Creyos Cognitive Composite - 3 Month — 0.27; 0.13 Change on z-score — p=0.346

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Brain Health Academy (Behavioral); Brain Health Together (Behavioral); Maintain Brain Health Together (Behavioral)
Age
Adult, Older Adult · 55+ yrs
Sex
All
Sponsor
University of California, San Francisco
Primary completion
Nov 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
Creyos Cognitive Composite - 3 Month		 0.27; 0.13 0.346
PRIMARY
Alzheimer's Disease Risk Index - Short Form-Change (ANU-ADRI-SF) - 3 Month Change		 0.00; -0.26 0.144
PRIMARY
Creyos Cognitive Composite - 6 Month Change		 0.30; 0.49; 0.10 0.28
PRIMARY
Alzheimer's Disease Risk Index - Short Form-Change (ANU-ADRI-SF) - 6 Month Change		 -0.19; -0.31; -0.43 0.58
SECONDARY
Loneliness / Social Isolation - 3 Month Change		 -0.11; -0.29 0.18
SECONDARY
Depression - 3 Month Change		 -0.26; -0.34 0.59
SECONDARY
Cognitive Activity - 3 Month Change		 0.22; 0.26 0.80
SECONDARY
Physical Activity - 3 Month Change		 0.18; 0.10 0.66
SECONDARY
Emotional Well-being - 3 Month Change		 0.13; 0.21 0.57
SECONDARY
Self-regulation - 3 Month Change		 0.14; 0.28 0.39
SECONDARY
Diet - 3 Month Change		 0.37; 0.20 0.19
SECONDARY
Sleep Disturbance - 3 Month Change		 -0.06; -0.13 0.63
SECONDARY
Self-efficacy/Confidence 3 Month Change		 0.00; -0.19 0.35
SECONDARY
Global Quality of Life - Physical - 3 Month Change		 0.18; 0.15 0.80
SECONDARY
Global Quality of Life - Mental - 3 Month Change		 0.05; 0.28 0.055
SECONDARY
Loneliness / Social Isolation - 6 Month Change		 -0.02; -0.34; -0.55 0.049 sig
SECONDARY
Depression - 6 Month Change		 -0.23; -0.42; -0.46 0.25
SECONDARY
Cognitive Activity - 6 Month Change		 0.10; 0.36; 0.36 0.10
SECONDARY
Physical Activity - 6 Month Change		 0.22; -0.11; 0.17 0.11
SECONDARY
Emotional Well-being - 6 Month Change		 0.17; 0.20; 0.18 0.85
SECONDARY
Self-Regulation - 6 Month Change		 0.09; 0.19; 0.34 0.61
SECONDARY
Diet - 6 Month Change		 0.34; 0.43; 0.43 0.54
SECONDARY
Sleep Disturbance - 6 Month Change		 -0.09; -0.15; -0.20 0.71
SECONDARY
Self-efficacy/Confidence - 6 Month Change		 -0.07; -0.31; -0.02 0.27
SECONDARY
Global Quality of Life - Physical - 6 Month Change		 0.12; 0.16; 0.19 0.83
SECONDARY
Global Quality of Life - Mental - 6 Month Change		 0.19; 0.35; 0.42 0.26

Summary

The purpose of this study is to develop and test a comprehensive Brain Health Together program for older adults living with cognitive decline.

Eligibility Criteria

Inclusion Criteria

  • English language fluency;*
  • live in U.S.;
  • cognitive decline (subjective cognitive decline OR diagnosis of mild cognitive impairment in the past 12 months)
  • ready to make lifestyle changes to improve brain health;
  • have 2 or more brain health risk factors (e.g., low physical activity, depression, hypertension, diabetes, etc)
  • have a desktop or laptop computer or iPad/tablet with a video camera;
  • have broadband internet access;
  • able to participate in online, live-streaming classes with two-way video

Exclusion Criteria

Candidates meeting any of the exclusion criteria will not be eligible to participate.

Alzheimer's disease or dementia

  • Major neurological disorder (e.g., Parkinson's disease, Multiple Sclerosis, amyotrophic Lateral Sclerosis)
  • Schizophrenia or other psychotic disorder
  • Autism or autism spectrum disorder
  • Major mood or anxiety disorder that is not well-controlled (e.g., symptoms of depression or anxiety that made it hard to do daily tasks in past 6 months)
  • Fracture of spine ("compression fracture") in the past 12 months
  • Vertigo or severe dizziness in the past 12 months
  • Severe vision or hearing impairment (e.g., unable to see and hear well enough to watch a movie on TV);
  • Stroke or heart attack in the past 12 months
  • Physical limitation that would restrict ability to participate (e.g., use wheelchair or walker to get around home, unable to stand up from sitting without assistance)
  • Currently in another research study that could confound results of this study (e.g., drug study or other study to improve brain health)
  • Previous participation in Moving Together or Brain Health Together
  • Limited life expectancy (e.g., enrolled in hospice, undergoing cancer treatment)

If participants are not sure about certain conditions, they will be asked to describe their condition, and the research team will determine whether they meet eligibility criteria or not.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05818423). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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