N/A
N=97
Influence of Stress on Encoding and Prediction
Stress · Learning, Spatial
Bottom Line
View on ClinicalTrials.gov: NCT05920161 ↗Enrolled (actual)
97
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcome: Primary: Changes in fMRI Signal — 0.261; -0.264 Pearson's rho — p=0.023
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Socially Evaluated Cold Pressor Test (Behavioral); Control (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Oct 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in fMRI Signal |
0.261; -0.264 | 0.023 sig |
| PRIMARY Statistical Learning |
0.692; 0.698; 0.694; 0.694; 0.686; 0.693 | 0.281 |
| PRIMARY Retention of Statistical Learning |
0.537; 0.477 | 0.143 |
| PRIMARY Episodic Memory |
0.067; 0.639; 0.590; 0.619; 0.615; 0.611 | <0.0001 sig |
| SECONDARY Cortisol Reactivity |
0.636; -0.252 | < 0.000 sig |
| SECONDARY Alpha-amylase Reactivity |
-0.286; -0.281 | 0.083 |
Summary
The purpose of this study is to investigate the neural mechanisms by which acute stress influences statistical learning and episodic encoding.
Eligibility Criteria
Inclusion Criteria
- 18-45 years old
- Fluent in English
- BMI 18-35
Exclusion Criteria
- Meeting current DSM-V criteria for any substance use disorder (except caffeine)
- Having current significant medical conditions or psychiatric symptoms requiring medication
- Current use of medications/drugs that interfere with physiological stress responses
- Peri and post-menopausal women, pregnant or lactating women, and those with hysterectomies
- Metal in body (for MRI safety) history will be assessed for female participants.
Data sourced from ClinicalTrials.gov (NCT05920161). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.