N/A
Completed N=58
Intensive Aerobic and Resistance Exercise Program (IAREP)
Type 2 Diabetes Mellitus · Mild Cognitive Impairment · Non-insulin-dependent Diabetes Mellitus · Cognitive Dysfunction
Source: ClinicalTrials.gov NCT06401733 ↗
Enrolled (actual)
58
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcomePrimary: Change in Cognitive Function Based on Risk Stratification Score (RSS) — -0.2; -0.1; -0.8; 0.0 score on a scale
Summary
A 12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention was implemented on high-risk and low-risk subjects with cognitive impairment in type 2 Diabetes Mellitus. The study aims to evaluate the effectiveness of IAREP on cognition, metabolic and inflammatory health, physical function, vascular health, and health practice behaviour in the Type 2 Diabetes Mellitus population (T2DM).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Cognitive Function Based on Risk Stratification Score (RSS) |
-0.2; -0.1; -0.8; 0.0 | — |
| PRIMARY Number of Participants With Change in Cognitive Function (Cognitive Impairment) Based on Vascular Dementia Battery (VDB) |
10; 16; 8; 14 | — |
| PRIMARY Change in Cognitive Function Based on the Montreal Cognitive Assessment (MoCA) |
25.0; 24.5; 25.0; 24.0 | — |
| SECONDARY Change in Metabolic Health |
— | — |
| SECONDARY Change in Inflammatory Condition |
— | — |
| SECONDARY Change in Short Physical Performance Battery (SPPB) |
— | — |
| SECONDARY Change in Sarcopenia Risk |
— | — |
| SECONDARY Change in Blood Pressure |
— | — |
| SECONDARY Change in Physical Activity: International Physical Activity Questionnaire - Short Form |
— | — |
| SECONDARY Change in Self-care of Diabetes Index (SCODI) |
— | — |
| SECONDARY Change in Self-related and Health Practice (SRAHP) |
— | — |
Eligibility Criteria
Inclusion Criteria
- Aged 40 to 85
- Living in the community
- Diagnosed with type 2 diabetes mellitus (T2DM)
- Literate in English or Mandarin
- Activities of daily living (ADL)-independent
- Obtain at least a score of 5 in short physical performance battery (SPPB) test
Exclusion criteria
- Severe cognitive (e.g., dementia) or psychiatric disorders (e.g., schizophrenia or severe depression)
- Severe hearing or vision impairments
- Terminally ill medical conditions (e.g., end stage cancer), severe cardiovascular, respiratory (e.g., respiratory failure), or orthopedic conditions (e.g., freeze shoulder)
- Absolute contraindications to aerobic exercise and resistance training programs (e.g., recent myocardial infarction or electrocardiography changes, complete heart block, acute congestive heart failure, unstable angina, uncontrolled hypertension)
- Pregnant or breastfeeding women
- Uncomfortable with video-recording of intervention sessions
Data sourced from ClinicalTrials.gov (NCT06401733). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.