Phase 4 N=47 Impact of Aripiprazole Once Monthly Medications on Changes in Brain Structure and Metabolism
Schizophrenia
Primary: Number of Participants With Changes in Fractional Anisotropy (FA) — 13; 9; 7 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=42 VO2 Max: In Vivo Model for Functional Red Cell Testing. Can RECESS be Explained?
Healthy
Primary: Percent Change From Baseline in Maximal Oxygen Uptake (VO2 Max) After Blood Cell Transfusion — 10.5; 8.5; 10.9 percent change
Phase 4 N=10 Effects of Ledipasvir/Sofosbuvir on the Pharmacokinetics and Renal Safety of Tenofovir Alafenamide (TAF)
Hepatitis C · HIV Coinfection
Primary: Change From Week 12 Plasma Tenofovir Area Under the Plasma Concentration vs. Time Curve From Time 0 to 24 Hours (AUC0-24) at 24 and 28 Weeks — 3466; 743; 868 ng*h/mL
Phase 4 N=6 Long-term, Open-label, Multicenter Study Assessing Long-term Cardiovascular Risks
Multiple Sclerosis
Primary: Participants Who Experienced at Least One Qualifying Cardiovascular Adverse Event — 0 participants
Phase 4 N=70 A Study of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Who Have Received Prior Treatment With Trastuzumab and a Taxane
HER2 Positive Breast Cancer, Metastatic Breast Cancer, Locally Advanced Breast Cancer
Primary: Severity of Adverse Events — 53; 40; 18; 2 Participants
Phase 4 N=41 Vortioxetine for Posttraumatic Stress Disorder
Post-Traumatic Stress Disorder
Primary: Change Clinician Administered PTSD Scale Score — 16; 17 score on a scale
Phase 4 N=69 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis · Plaque, Dental · Periodontal Diseases
Primary: Degree of Plaque as Assessed by the Turesky Modification of the Quigley-Hein Plaque Index — 0.41; 0.43 score on a scale
Phase 4 N=102 Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction
Anesthesia Intubation Complication
Primary: Estimated Propofol Doses Producing 50% Excellent Intubation Conditions — 1.48; 0.00; 0.07; 2.35 mg/kg
Phase 4 N=40 Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI
Diabetes Mellitus, Type 2 · Coronary Artery Disease
Primary: P2Y12 Reaction Units (PRU) — 60; 146 PRU — p=0.001
Phase 4 N=179 Arresting Vertical Transmission of Hepatitis B Virus
Hepatitis B · Vertical Transmission of Infectious Disease
Primary: Number of Participants With Lab Testing Acceptability Survey Scores >80% — 7; 41; 7; 40 Participants
Phase 4 N=288 Efficacy, Safety, and Pharmacokinetics of Sugammadex for Reversal of Neuromuscular Blockade (NMB) in Pediatric Participants (MK-8616-089)
Neuromuscular Blockade
Primary: Area Under the Plasma Concentration-Time Curve (AUC) From Dosing to Infinity (AUC0-∞) of Sugammadex [Part A] — 14.1; 18.8; 27.6; 26.9 hr*μg/mL
Phase 4 N=32 Fibrinolysis Compared to Thoracoscopy for Pleural Infection
Pleural Infection · Empyema · Pleural Diseases
Primary: Duration of Hospital Stay After Intervention — 4; 2 days
Phase 4 N=468 A Study to Evaluate Cooling Sensation of an Allergy Product in Adults With a History of Allergies
Allergic Rhinitis
Primary: Proportion of Participants With Agreement of Perception of Cooling Sensation — 0.99 Proportion of participants
Phase 4 N=45 Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department
Abdomen, Acute · Other Acute Pain · Flank Pain
Primary: Maximal Change in Numerical Rating Scale (NRS) Pain Score From Baseline NRS Pain Score — -4.9; -5 NRS pain scale score
Phase 4 N=156 Vaccinating Children After Chemotherapy
Acute Lymphoblastic Leukemia
Primary: Percentage of Participants With Protective Titres to PCV13 Serotypes Post-immunization With PCV13+PPV23 — 40; 22 Participants