65,437 trials
Major Depressive Disorder
Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Score: Pre- Minus Post-treatment Intervention — 7.1 Score on a Scale — p=<0.05
HIV-1 Infection
Primary: Percentage of Participants Who Experienced One or More Adverse Events (AEs) During the Double-Blind Treatment Period +42 Days Post-Blind — 75.0; 75.6; 80.0; 67.5…
Duchenne Muscular Dystrophy Cardiomyopathy · Cardiomyopathy, Dilated
Primary: Incidence of Treatment-Emergent Adverse Events — 14; 9; 10 Participants
Chronic Pain
Primary: Change in Pain Interference 6-item Subscale From PROMIS-43 Adult Profile — -3.3; -3.7 score on a scale — p=0.84
Neoplasms · Carcinoma, Non-Small-Cell Lung
Primary: Dose Escalation: Maximum-tolerated Dose (MTD) of the BI 754111 Plus Ezabenlimab Combination — NA Milligram
Women's Health · Insomnia · Sleep Disturbance
Primary: Change in Quality of Sleep — -3; -4; -1 score on a scale
RSV Infection
Primary: Number of Participants With Challenge-related Adverse Events — 0; 3 Participants
Bronchopulmonary Dysplasia of Newborn
Primary: Safety Based Upon Number of Participants With Hypotension — 1; 0; 0; 0 Participants
Prostatic Neoplasms
Primary: Percentage of Patients With Castrate Level of Serum Testosterone — 25 Participants
ACL · Anterior Cruciate Ligament Injuries
Primary: Mean Opioid Consumption at 24 Hours — 21.5; 19.9 morphine milligram equivalents — p=0.17
Excessive Daytime Sleepiness · Obstructive Sleep Apnea · Impaired Cognitive Function
Primary: Change From Baseline in the Average of the DSST RBANS Scores at the End of Each Double-blind Treatment Period — 6.49; 4.75 score on a scale — p=0.009
Covid19
Primary: Body Temperature — 98.1 degrees Fahrenheit
Hepatic Impairment · Healthy
Primary: Pharmacokinetic (PK) Parameter: AUCtau of Bulevirtide (BLV) — 152; 150; 215; 113 h*ng/mL
Arthroplasty, Replacement, Hip
Primary: Survivorship of the Device — 97.03; 98.27 percentage of participants not revised — p=0.4551
Osteoarthritis, Knee · Knee Pain
Primary: Change in Knee Injury and Osteoarthritis Outcomes Score (KOOS) Score - Pain — 64.4; 62.5; 63.9; 13.2 score on a scale — p=0.594