65,437 trials
Anaemia
Primary: Time to First Occurrence of Adjudicated Major Adverse Cardiovascular Event (MACE) During Cardiovascular (CV) Events Follow-up Time Period (Non-inferiority Analysis)…
Hematopoietic Cell Transplantation Recipient · Malignant Neoplasm · Influenza
Primary: Immunogenicity as Measured by the Number of Subjects Who Achieve a 4-fold (or Greater) Rise in Post-vaccination HAI Titers — 0.20; 0.20; 0.42; 0.31 proportion of…
Type2 Diabetes
Primary: Lipoprotein-associated Phospholipase A2 — 238.4 ng/ml
Dry Eye
Primary: Coprimary Endpoint: Change From Baseline in Inferior Corneal Fluorescein Staining Score to Day 57 (Pre- to Post-CAE) — 1.38; 1.31; -0.47; -0.52 score on a scale — p=0.1871
Cardiovascular Diseases
Primary: Composite of CV Death, Nonfatal MI (Including Silent MI), Nonfatal Stroke, Coronary Revascularization, or Unstable Angina Determined to be Caused by Myocardial Ischemia…
Refractive Errors
Primary: Residual Refractive Cylinder — 0.04 diopters
Peri-implant Mucositis
Primary: Global Probing Depth — 2.37; 2.64 mm — p=0.28
Stage IIIC Melanoma · Stage IV Melanoma
Primary: Percentage of Participants With Immune-related Overall Response Rate (irORR) — 9.5; 3.1 percentage of participants
SARS-CoV 2 · COVID-19
Primary: Number of Participants With COVID-19 Antibodies — 8; 284 Participants — p=>0.18
Advanced Cholangiocarcinoma · Metastatic Cholangiocarcinoma
Primary: Progression Free Survival (PFS) as Determined by the Independent Radiology Committee (IRC) — 2.7; 1.4 months — p=<0.0001
Mucositis
Primary: Percentage of Participants With Severe (WHO Grade 3-4) Oral Mucositis — 23 percentage of participants
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
Primary: Objective Response Rate, Defined as the Percentage of Subjects With a Best Overall Response of Confirmed Complete Response (CR) or Partial Response (PR) — 69.3; 64.0…
Increased Risk of SARS-CoV-2 Infection
Primary: Negative Polymerase Chain Reaction (PCR) — 2; 7 Participants
Acne Vulgaris
Primary: Global Acne Grading System Score — 32; 30.33; 21.67; 27.5 score on a scale
Migraine
Primary: Headache Days — 5.1; 5.2 Headache days per 4 weeks