Early Phase 1 N=28 Sensory and Opioid Mechanisms of Affective Touch
Pain · Touch
Primary: Change in Pleasantness of Skin Brushing From Before to After Infusion — -9.6875; -4.9583 Units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=90 Prevalence of Lidocaine Ineffectiveness in Adults With and Without ADHD
ADHD · PMS
Primary: Number of Subjects With Lidocaine Ineffectiveness — 11; 9; 16; 5 Participants — p=0.017
Early Phase 1 N=20 A Study of the Effect of Quizartinib on the Pharmacokinetics of the P-gp Substrate Dabigatran Etexilate in Healthy Participants
Healthy Subjects · Drug-drug Interaction · Pharmacokinetics
Primary: Maximum Plasma Concentration (Cmax) of Total Dabigatran and of Free Dabigatran Following a Single Dose in Participants Without and With Concomitant Quizartinib — 192…
Early Phase 1 N=28 Observational Study to Assess the Frequency of Lidocaine Ineffectiveness in Hard-to-treat ADHD
ADHD
Primary: Observational Study: Number of Participants With Lidocaine Ineffectiveness by Taste Test in Hard-to-treat ADHD — 1; 27 Participants
Early Phase 1 N=16 Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy Participants
Moderate Hepatic Impairment
Primary: Maximum Plasma Concentration (Cmax) of Pexidartinib Following a Single Dose in Participants With Moderate Hepatic Impairment Compared to Healthy Participants — 1420…
Early Phase 1 N=50 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer
FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma · FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma · FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma
Primary: Mean Post-treatment Tumor Progesterone Receptor H-score (Histology Score) — 53.6; 42.7 units on a scale — p=0.87
Early Phase 1 N=26 The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Headache · Post-Concussion Syndrome
Primary: Immediate Change in Headache Scores With a Visual Analog Scale (VAS) — 5.6; NA; 3.5; NA units on a scale
Early Phase 1 N=53 Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine
Nicotine Addiction · Panic Attack
Primary: Smoking Abstinence — 8.25; 12.35 percentage of participants
Early Phase 1 N=54 Effect of Pembrolizumab (Keytruda®) on Biomarkers in Early Breast Cancer.
Breast Cancer · Triple Negative Breast Cancer · Hormone Receptor Negative Neoplasm
Primary: PD-1 Expression — 0; 0; 0; 0 percentage
Early Phase 1 N=40 Exercise Training Effects on Metabolic Syndrome: Interactions With Medication
Exercise Therapy · Metabolic Syndrome X · Cardiorespiratory Fitness
Primary: Systolic Blood Pressure — 126; 134; 124; 133 mmHg — p=0.040
Early Phase 1 N=48 Donor Stem Cell Transplantation for Congenital Immunodeficiencies
Inherited Immune Deficiencies
Primary: Stem Cell Transplant Engraftment — 7; 31; 3; 0 Participants
Early Phase 1 N=15 Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers
Pre-Exposure Prophylaxis
Primary: Plasma TFV AUC0-INF GMR — 8.75; 8.27 ng*h/mL
Early Phase 1 N=6 Ketamine for Depression Relapse Prevention Following ECT
Depression
Primary: Completion Rate for Randomised Treatment — 0; 0 Participants
Early Phase 1 N=13 Neoadjuvant Itraconazole in Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
Primary: Changes in Tumor Tissue Microvessel Density [MVD] From Baseline — 0.005 Percent area fraction
Early Phase 1 N=49 Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Change in Urinary Excretion of the Mercapturic Acid of Benzene Following 4 Tablets Per Day of Avmacol — 1.16 data presented as ratio; no unit