30 closest matches · ranked by relevance
Pediatric Acute-Onset Neuropsychiatric Syndrome
Primary: Percentage Change in CY-BOCS Score From Baseline to Week 9 — 12.1; 31.1 Percentage Change at Week 9 to Baseline — p=0.0718
Obsessive-Compulsive Disorder · Children · Anxiety Disorder
Primary: Children's Yale-Brown Obsessive Compulsive Scale Total Score — 20.59; 25.67 units on a scale — p=0.44
PANS · PANDAS · Obsessive Compulsive Disorder (OCD)
Primary: Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) — 29.49; 28.43; 20.53; 23.45 units on a scale
Partial-Onset or Primary Generalized Tonic-Clonic Seizures
Primary: Percentage of Participants With Treatment Emergent Adverse Events (AEs) and Treatment Emergent Serious Adverse Events (SAEs) for Total Group of Participants - Core Phase…
Irritability Associated With Autism Spectrum Disorder
Primary: Change From Baseline at Week 6 in Caregiver-rated Aberrant Behavior Checklist Irritability (ABC-I) Subscale Score — -9.6; -11.2; -11.2 score on a scale — p=0.2986
Inflammatory Bowel Disease
Primary: Pediatric INTERMED- Complexity Index — 24; 9.0; 4.0; 4.0 scores on a scale
Obsessive-Compulsive Disorder
Primary: OCD Severity at 12 Weeks — 21.4; 21.3 points on a scale
Pervasive Developmental Disorder
Primary: Number of Participants Improved as Measured by the Clinical Global Impression-Global Improvement Scale (Improvement Defined as CGI-I=1 or CGI-I=2) — 11; 3 participants
Bipolar Disorder
Primary: Mean Change in the Young Mania Rating Scale (YMRS) Score — -8.1 score on a scale
Acute Respiratory Distress Syndrome
Primary: 28 Day Mortality in Pediatric ARDS. — 44 Participants — p=<0.05
Bipolar Disorder
Primary: Number of Participants Who Experienced Clinical or Laboratory Adverse Events — 197; 74 Participants
Concussions · PCS
Primary: Count of Children Who Have Persistent Post-concussive Symptoms (PCS) at One-month Follow-up. — 510; 291 Participants
Autistic Disorder
Primary: Mean Change From Baseline in the Aberrant Behavior Checklist Japanese Version (ABC-J) Irritability Subscale Score — -11.4; -7.5 units on a scale
Autism · Attention Deficit Hyperactivity Disorder
Primary: Change From Baseline in Attention Deficit Hyperactivity Disorder Symptom Checklist (ADHD-SCL) — -8.5 change in scale score
Bipolar Disorder
Primary: Young Mania Rating Scale (YMRS) — 12.70; 12.57 units on a scale
Autism Spectrum Disorder (ASD) · Autism · Autistic Disorder
Primary: Number of Confirmed Social Responsiveness Scale (SRS) Responders — 517; 351 participants
Phelan McDermid Syndrome
Primary: ABC - Social Withdrawal Subscale — 10.31; 4.6; 14.8; 6.2 score on a scale
Phelan-McDermid Syndrome · Epilepsy
Primary: Number of Adverse Events — 19 events
Pantothenate Kinase-Associated Neurodegeneration
Primary: Number of Treatment-emergent Adverse Events Assessed Using CTCAE v4.0 — 1.15; 1.38; 1.14; 0.86 Events per person — p=0.50
Schizophrenia
Primary: Change From Baseline in the Positive and Negative Syndrome Scale (PANSS) Total Score at Week 6. — 94.5; 94.0; 92.8; -18.6 units on a scale — p=0.0003
Pseudohypoparathyroidism · Albright Hereditary Osteodystrophy
Primary: Intelligence Quotient — 85.9; 104.3; 103.2 units on a scale
Schizophrenia · Autism
Primary: Lurasidone Primary Pharmacokinetic Parameters — 78; 140; 300; 115 ng.h/mL
Type 1 Diabetes
Primary: Safety Endpoint (Tested for Non-inferiority Compared to Baseline) CGM Measured (a) — 0.3; 0.3 percentage of time
Pediatric Bipolar Spectrum Disorders
Primary: Improvement in Mania Symptoms by Change in Young Mania Rating Scale (YMRS) — -4.8; -6.4; -10.2 units on a scale
Autistic Disorder · Asperger Syndrome · Autism Spectrum Disorder
Primary: Change From Baseline in Aberrant Behavior Checklist-Irritability at 12 Weeks — 7.6; -0.6 units on a scale
Autism Spectrum Disorder
Primary: Change From Baseline in the Pervasive Developmental Disorder-Behavioral Inventory (PDDBI) - Autism Composite Score — -4.5; -6.4 units on a scale — p=0.5
Cryopyrin-associated Periodic Syndromes · Familial Cold Autoinflammatory Syndrome · Muckle-Wells Syndrome
Primary: Percentage of Participants Aged 4 Years or Younger With at Least One Complete Response at Week 56 — 94.1 Percentage of participants
Autistic Disorder
Primary: Mean Change From Baseline at the Final Assessment in Aberrant Behavior Checklist Japanese Version (ABC-J) Irritability Subscale Score — -3.2 units on a scale
Autistic Disorder · Behavioral Symptoms
Primary: Number of Participants With Serious Adverse Events (SAEs), Treatment-Emergent Adverse Events (AEs), Deaths, AEs Leading to Discontinuation, Extra Pyramidal Syndrome…
Bipolar Disorder, Pediatric
Primary: Change From Baseline in Y-MRS Total Score at Day 21 — -9.6; -12.3; -15.1; -15.9 score on a scale — p=0.008