Phase 3 N=147 Corneal Collagen Cross-linking for Progressive Keratoconus
Progressive Keratoconus
Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -1.7; 0.6 diopters
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Phase 3 N=239 Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
Progressive Keratoconus
Primary: Difference Between Treatment Groups in the Change From Baseline to Month 6 in Kmax — -0.3; 0.6 Diopters — p=0.0004
Phase 2 N=510 Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
Keratoconus · Post-Refractive Ectasia
Primary: Change in Maximum Keratometry From Baseline to 6 Months After Treatment — 0.76; 0.97 diopters
N/A N=94 Simultaneous TransPRK and Corneal Collagen Cross-Linking
Keratoconus
Primary: Change in LogMAR Corrected Distance Visual Acuity (CDVA) — -0.13; -0.05 LogMAR CDVA — p=0.03
N/A N=127 Controlling Myopia Progression With Soft Contact Lenses (Contact Lens Control)
Myopia
Primary: Spherical Equivalent Refractive Error — -0.386; -0.185; -0.679; -0.548 diopter (D)
N/A N=12 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus
Keratoconus
Primary: Number of Participants With Normal Vision — 8 Participants
N/A N=152 Controlling Myopia Progression With Soft Contact Lenses
Myopia
Primary: Axial Length (Axial Elongation) — 0.158; 0.144; 0.121; 0.242 millimeter (mm)
N/A N=137 Controlling Myopia Progression With Soft Contact Lenses
Myopia
Primary: Spherical Equivalent Refraction — -0.326; -0.460; -0.430; -0.898 diopter (D)
N/A N=30 Transepithelial Corneal Cross-linking Using Iontophoresis
Progressive Keratoconus
Primary: K-max — -0.52; -0.82 Diopters (D) — p=<0.05
Phase 3 N=130 Corneal Collagen Cross-Linking for Ectasia (CXL)
Ectasia
Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -0.5; 0.5 diopters
N/A N=45 Effectiveness of Orthokeratology in Myopia Control
Myopia
Primary: Axial Length — 25.32; 26.08 mm
N/A N=18 Corneal Topographer Fluorescein Patterns
Keratoconus
Primary: Number of Participants With an Observable Difference Between Virtual Versus Actual Fluorescein Patterns — 0 participants
Phase 2 N=68 Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit
Keratolysis
Primary: Time From Surgery to Device Loss or Replacement — 95; 34 median weeks from surgery to removal
N/A N=86 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents.
Myopia · Esophoria · Fixation Disparity
Primary: Changes in Cycloplegic Autorefraction in One Year. — -0.22; -0.78 Diopters
N/A N=82 Myopia Progression After Ceasing Myopia Control Contact Lens Wear
Myopia
Primary: Axial Length of the Eye — 0.080; 0.073; 0.229; 0.231 millimeter (mm)
N/A N=102 Retardation of Myopia in Orthokeratology
Myopia
Primary: Axial Elongation in the Study and Control Subjects Who Completed the Two Years Study — 0.36; 0.63 mm
N/A N=50 Theranostic Guided Riboflavin/UV-A Corneal Cross-linking
Keratoconus
Primary: Validation of the Theranostic Scores — 91; 95 Percentage
N/A N=36 Investigation of the Effect of Short-term Orthokeratology With Increased Compression Factor on Ocular Parameters
Myopic Progression
Primary: Changes in Spherical Equivalent Refraction — 2.31; 2.52 D
Phase 3 N=118 Correction of Myopia Evaluation Trial 2
Myopia
Primary: Distribution of Change in Spherical Equivalent Refractive Error From Baseline to 3 Years — 6; 3; 11; 8 participants
N/A N=144 An Evaluation of the Effectiveness of Dual Focus Soft Contact Lenses in Slowing Mypoia Progression
Myopia
Primary: Change in Refractive Error Relative to Baseline — -0.18; -0.58 Diopters
Phase 2 N=1 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Chemical Injuries · Unspecified Complication of Corneal Transplant · Autoimmune Diseases
Primary: Changes in Corneal Thickness at 1 Millimeter — 730; 760; 700; 720 micrometer
N/A N=80 Assessment of Three Basic Progressive Lens Designs
Presbyopia
Primary: Evaluate the Adaptation to Progressive Lens Designs. — 4.125; 4.025; 3.875; 3.725 score on a scale
N/A N=294 Bifocal Lenses In Nearsighted Kids
Refractive Errors
Primary: Refractive Error Progression — -3.46; -3.32; -2.84 Diopters — p=<0.01
N/A N=59 Corneal Biomechanics and Corneal Reshaping Therapy
Myopia
Primary: Change of Corneal Stiffness From Baseline at 6 Months — 0.061 N/mm
Phase 3 N=147 Cross-linking for Corneal Ulcers Treatment Trial
Corneal Ulcer · Infectious Keratitis · Bacterial Ulcer
Primary: Microbiological Cure on Repeat Culture — 5; 5; 17; 14 Participants
N/A N=40 Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
Corneal Wound Healing
Primary: Number of Days to Complete Re-epithelialization — 4.6; 4.1 days to complete re-epithelialization
N/A N=53 Discontinuation of Orthokeratology on Eyeball Elongation in Myopic Children
Myopia
Primary: Change in Axial Length — 0.153; 0.087; 0.082; 0.059 mm
N/A N=92 Evaluation of the Efficacy in Decreasing Myopia Progression of the Proposed Ophthalmic Lens Prototypes
Myopia
Primary: Axial Lenght Increase — 0.27; 0.37 mm
Phase 2 N=10 A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
Persistent Corneal Epithelial Defect
Primary: Percentage of Patients Achieving Corneal Healing (<0.5 mm2 Lesion Size) of the Persistent Corneal Epithelial Defect at 4 Weeks — 5 Participants
N/A N=46 Treating Contact Lens Discomfort With Orthokeratology
Dry Eye · Contact Lens Complication
Primary: Contact Lens Comfort — 22.03; 9.83 Units on a Scale — p=<0.001