65,437 trials
Stable Coronary Heart Disease
Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs) and Treatment Emergent Serious Adverse Events (TESAEs) — 17; 10; 11; 12 Participants
Breast Cancer · Non-small Cell Lung Cancer · Melanoma
Primary: Percentage of Participants Achieving Complete Response (CR) or Partial Response (PR): Objective Intracranial Response Rate (OIRR) — 0; 5.8; 0; 0 percentage of participants
Healthy Volunteers · Endotoxemia
Primary: Prothrombin Fragments f1+2 — 31.1; 34.08; 27.41; 36.02 fold-change*h — p=0.408
Hypotension and Shock · Excessive Amount of Blood / Fluid Infusion
Primary: Percentage of Participants With Systemic Hypotensions — 68; 46; 65 Participants
Microsatellite-instability (MSI) High Colorectal Cancer (CRC) · Endometrial Cancer · Head and Neck Cancer
Primary: Phase 1: Percentage of Participants With Treatment-Emergent Adverse Events (TEAE) and Serious Treatment-Emergent Adverse Events — 0; 40.0; 50.0; 45.0 Percentage of…
Abdominal Aortic Aneurysm
Primary: Mortality — 111; 112; 133; 130 Participants
Friedreich Ataxia
Primary: Change From Baseline in the Inverse Time to Complete the 9-Hole Peg Test (9-HPT-1) — 0.00038; -0.00017; -0.00032 1/seconds — p=>0.999
Pain
Primary: Change in Patient-perceived Pain Between Baseline and Cannulization — 29.5; 35 score on a scale
Immune Response
Primary: HI Titers, HD vs. AD, Yr 1 Day 28 Post Vaccination — 175; 117; 144; 118 Titer
Latent Tuberculosis Bacteriology and Histology Unknown · Latent Tuberculosis
Primary: Number and Percentage of Unsolicited and Solicited Adverse Events Recorded Post Day 0 Vaccination. — 7; 8; 15; 15 Participants
Fungal Infection
Primary: Steady State (ss) Average Concentration (Cavg) of Posaconazole of Serial PK (Subgroup 1) on Day 10 — 2986.28 ng/mL
Schizophrenia · Autism · Bipolar Depression
Primary: Number of Subjects With Adverse Events (AEs), Discontinuations Due to AEs and Serious AEs (SAEs) — 214; 106; 252; 572 Participants
Osteoarthritis · Rehabilitation
Primary: Total WOMAC Score — 51.64285714; 52.47619048; 39.60714286; 40.38095238 score on a scale
Pancreatic Carcinoma
Primary: Percentage of Patients Discharged by Post-operative Day 5 — 5; 28 Participants
Islet Transplantation in Diabetes Mellitus Type 1
Primary: Area Under the Curve (AUC) for the Serum C-peptide Level During the First 2 Hours of an MMTT (Mixed Meal Tolerance Test), Normalized by the Number of Islet Equivalent…