Phase 3 N=11 Timed Release Tablet Prednisone in Polymyalgia Rheumatica
Polymyalgia Rheumatica
Primary: Change in Peak Serum IL-6 Concentration — 11.5; 29.3 pg/ml — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=878 A Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Patients With Active Rheumatoid Arthritis Despite Anti-TNF-Alpha Therapy (SIRROUND-T)
Arthritis, Rheumatoid
Primary: Percentage of Participants Achieving American College of Rheumatology (ACR) 20 Response at Week 16 — 24.1; 40.1; 45.2 Percentage of Participants — p=< 0.001
N/A N=20 Precise Measurement of Pediatric Defibrillation Thresholds
Pediatrics · Defibrillators, Implantable
Primary: Defibrillation Threshold — 7 Joules
N/A N=40 Galilei Lens Professional vs. Predicate Devices: a Comparison Study
Cataract
Primary: Agreement With Predicate Devices in Terms of Agreement 1 — -0.010; -0.023; -0.014; 0.005 Units are mm — p=0.09
Phase 3 N=486 Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee
Osteoarthritis of the Knee
Primary: Change From Baseline to Week 12 in the Weekly Mean of the Average Daily (24-hr) Pain (ADP) Intensity Scores for 32 mg FX006 Versus Placebo — -3.12; -2.14 units on a…
N/A N=40 Effect of EPA and DHA in the Inflammation and Metabolic Disorders in DMD/DMB Patients
Muscular Dystrophy, Duchenne
Primary: Body Composition (Body Fat) — 172.1; 232.7; 180.2; 274.8 g/Kg of body weight — p=<0.05
Phase 2 N=37 Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)
Alzheimer's Disease · Mild Cognitive Impairment
Primary: Verbal Memory Composite — -.31247583; .33390008; -.05181561 Change in Z score memory composite
N/A N=29 DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation
Refractive Error
Primary: Tear Film Evaporation Rate — 120.88; 105.63 gm^-2 h
N/A N=41 Vitamin B12 for Aromatase Inhibitors Musculoskeletal Symptoms
Relief of Joint Pain
Primary: Percentage Change in Average Joint Pain in Women With Aromatase Inhibitor-associated Musculoskeletal Symptoms (AIMSS) Compared to Baseline as Measured by the Brief Pain…
Phase 4 N=597 Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty
Saphenous Vein Graft Atherosclerosis
Primary: Number of Participants With Target Vessel Failure (TVF), Defined as the Composite of Cardiac Death — 16; 17 Participants
Phase 3 N=12 An Open Label Multi-center Extension Study to Evaluate Long-term Safety/ Tolerability of Dovitinib in Patients With Solid Tumors Who Continue to Receive Treatment With Dovitinib (TKI258) in Novartis-sponsored Single Agent Dovitinib Studies Which Fulfilled the Requirements for the Primary Objective
Solid Tumors
Primary: Number of Participants With Adverse Events of Grades 3 and 4 Severity — 6; 2; 1; 0 Participants
Phase 2 N=43 A Study to Examine the Effects of an Experimental Drug on Women With Breast Cancer and Metastatic Bone Disease (MBD)(0822-016)(COMPLETED)
Breast Cancer · Metastatic Bone Disease
Primary: Percentage Change From Baseline in Urinary N-telopeptide of Type I Collagen (u-NTx) at Week 4 — -73; -77 Percentage change
Phase 2 N=224 Preventing Complications in Cleft Palate Repair With Antibiotics
Cleft Palates
Primary: Number of Participants With Fistula or Delayed Wound Healing Following Palatoplasty — 3; 2; 18; 21 Participants
Phase 2 N=36 Open Label Phase Two Trial of Radium Ra 223 Dichloride With Concurrent Administration of Abiraterone Acetate Plus Prednisone in Symptomatic Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Bone Metastasis
Prostate Cancer
Primary: Number and Percentage of Participants With Clinically Meaningful Improvement (Between Baseline and End of Treatment) in Quality-of-Life Determined by the Minimum…
N/A N=94 Medication Treatment for Depression in Nursing Home Residents
Depression
Primary: Geriatric Depression Scale (GDS) Score — 5.11; 5.03; 4.59; 4.64 units on a scale