Phase 4 N=120 Treating Acutely Agitated Patients With Asenapine Sublingual Tablets
Agitation
Primary: Positive and Negative Syndrome Scale - Excited Component — 7.86; 14.93 PANSS SCORE
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=240 An Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Spinal Disorders
Spinal Disorders
Primary: Change From Baseline in Pain Intensity of Patient With Spinal Disorder as Measured by NRS. — -1.69 scores on a scale — p=<0.05
Phase 4 N=140 A Study of Once Monthly Bonviva (Ibandronate) in Prevention of Glucocorticoid-Induced Osteoporosis.
Postmenopausal Osteoporosis
Primary: Percent Change From Baseline in Mean Lumbar Spine Bone Mineral Density (BMD) at Month 12 — 3.2; -0.1 percent change in BMD — p=<0.001
Phase 4 N=36 Ticagrelor China Pharmacokinetic/Pharmacodynamic Study
Stable Coronary Heart Disease (CHD)
Primary: IPA on Day 1 — 27.09; 25.87; 33.34; 57.20 % IPA
Phase 4 N=5,570 A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313)
Type 2 Diabetes Mellitus
Primary: Change From Phase 2 Baseline to Week 44 in Hemoglobin A1c (HbA1c) Levels (Phase 2) — -0.65; -0.62; -0.46; -0.69 Percent
Phase 4 N=14 A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD
Chronic Kidney Disease · Poorly-Controlled Hypertension
Primary: Change of Systolic Ambulatory Blood Pressure From Baseline to 12 Weeks — -10.5 mmHg — p=0.01
Phase 4 N=60 Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
Foot and Ankle Procedures
Primary: Postoperative Pain — 0.21; 0.05 Scores on a scale
Phase 4 N=21 Pharmacokinetic Profile of Myfortic in Combination With Tacrolimus in Fed Versus Fasting State
Kidney Transplantation
Primary: Maximum Observed Plasma Concentration (Cmax) of Mycophenolic Acid (MPA) — 12.8; 18.7 micrograms per milliliter — p=0.0163
Phase 4 N=30 Effect of Electronic Cigarette Use on Cough Reflex Sensitivity
Cough
Primary: Change in Cough Reflex Sensitivity (Log C5) — -0.29; 0.24 log C5
Phase 4 N=10,000 Post-licensure Safety Study of IMOJEV® in Thailand
Japanese Encephalitis
Primary: Number of Participants Experiencing a Grade 3 Immediate Systemic Adverse Events and Serious Adverse Events Following Any Vaccination With IMOJEV® — 0; 0; 204; 59…
Phase 4 N=2,681 PROMUS Element Plus US Post-Approval Study
Coronary Artery Disease
Primary: Cardiac Death or Myocardial Infarction Rate in PLATINUM-like Patients — 1.78 percentage of patients — p=<.0001
Phase 4 N=66 A Study of Bone Turnover Markers in Post-Menopausal Women With Osteoporosis Treated With Monthly Boniva (Ibandronate)
Post Menopausal Osteoporosis
Primary: Relative Percent Change in Serum C-terminal Telopeptide of Type 1 Collagen Concentration (sCTX) From Baseline to Day 3 — -70.16; -5.96 Percent change — p=< 0.0001
Phase 4 N=8,144 Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders
Smoking Cessation
Primary: Occurrence of Neuropsychiatric (NPS) Adverse Events (AE) - the Primary Study Endpoint — 1.3; 2.2; 2.5; 2.4 percentage of participants — p=0.0652
Phase 4 N=33 Evaluation of the Autonomic Nervous System During First-dosing With 0.5mg of Fingolimod (Gilenya) in Patients With Relapsing-remitting MS
Multiple Sclerosis · Autonomic Nervous System Dysfunction
Primary: RMSSD Normal Breathing — 14.10 milliseconds — p=0.02
Phase 4 N=48 Effect of Intravitreal VEGF-Trap Eye on Polypoidal Choroidal Vasculopathy
Exudative Age-related Macular Degeneration · Polypoidal Choroidal Vasculopathy
Primary: Percentage of Patients Lose Visual Acuity Less Than 15 Letters — 87.5 percentage of patients