12,372 trials
Chronic Idiopathic Constipation
Primary: Observed Spontaneous Bowel Movement (SBM) Count Within 1 Week — 1.38; 1.37; 1.35; 3.68 SBMs/week — p==0.0020
Depression · Major Depressive Disorder
Primary: Time to Relapse (Days) — NA; NA Days
Acne
Primary: Percent Change in Baseline Acne Lesions at Week 12 — -32.34; -37.32; -26.38 Percent reduction
Carcinoma, Non-Small-Cell Lung
Primary: Best Overall Response Rate (ORR), Based on Unconfirmed Response Assessment, as Assessed by Central Imaging Review Until 18 Weeks After the Start of Treatment — 54.0…
Cryptococcal Meningitis · Fungal Meningitis
Primary: Survival — 125; 109 Participants
Chronic Pain · Osteoarthritis, Hip · Osteoarthritis, Knee
Primary: Percentage of Participants With Adjudicated Primary Composite Joint Safety Outcome — 3.9; 7.1; 1.5 percentage of participants — p=0.0123
Constipation Predominant Irritable Bowel Syndrome
Primary: Percent Complete Spontaneous Bowel Movement Responders vs Placebo — 35; 38; 51; 30 Participants — p=<0.001
Pigmented Villonodular Synovitis · Giant Cell Tumors of the Tendon Sheath · Tenosynovial Giant Cell Tumor
Primary: Percentage of Participants With Symptomatic, Locally Advanced Tenosynovial Giant Cell Tumor (TGCT) Achieving Complete or Partial Response to Pexidartinib Compared With…
Head and Neck Cancer · Precancerous Condition
Primary: Overall Survival — 84.6; 77.9 percentage of participants
Multiple Myeloma
Primary: Progression-free Survival (PFS) — 31.87; NA Months — p=<0.0001
Lung Cancer
Primary: Overall Survival (OS) — 7.46; 8.38 Months — p=0.1144
Systemic Lupus Erythematosus
Primary: Number of Participants With Adverse Events (AEs) and Serious AEs (SAEs) — 48; 139 Participants
Chronic Kidney Disease · Metabolic Acidosis
Primary: Sit to Stand to Sit Speed: Time Taken to Sit to Stand to Sit 10 Times — 23.8; 22.9 seconds
Diabetes Mellitus, Type 2
Primary: The First 3-point Major Adverse Cardiovascular Events (3P-MACE) — 20.7; 21.2 Events/ 1000 patients-years — p=<0.0001
HIV-1
Primary: Percentage of Participants With Human Immunodeficiency Virus (HIV)-1 Ribonucleic Acid (RNA) Less Than (<) 50 Copies Per Milliliter (Copies/mL) (Virologic Response) at…