Clinical Trial Search

Primary: Hb Level 48 Hours After Total Knee Arthroplasty — 10.92; 10.23 gr/dL

Primary: Stage 1 and 1A: Number of Participants With Dose Limiting Toxicities (DLTs) — 0; 0; 0; 0 participants

Primary: Absolute Bioavailability After a Single Oral Dose of Hetlioz™(Tasimelteon) 20mg — 38.3 Geometric Mean Ratio (%)

Primary: Participant's Subjective Rating for Lens Handling - Enfilcon A / Omafilcon A — 97; 84 units on a scale

Primary: Received Minute Volume (Liters) as Measured by Wright Respirometer — 6.8; 5.2 Liters — p=<0.001

Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm

Primary: Percentage of Participants Maintaining Average Hemoglobin Concentration During Efficacy Evaluation Period (EEP) Within Target Range — 41 percentage of participants

Primary: Mean Change in Massachusetts General Hospital Hairpulling Scale Baseline to Post-treatment — 6.695 Units on a scale — p=<0.05

Primary: Change in Hemoglobin A-1C From Baseline — -0.16; -0.50 percentage of glycolsylated hemoglobin — p=0.0757

Primary: Percentage of Responders (Primary Medical Treatment in Arm 1, Primary Surgical Treatment in Arm 2) — 6.7; 50 percentage of participants

Primary: Change in Alanine Aminotransferase (ALT) — -37.8; -14.9 U/L — p=0.0195

Primary: Heat Pain Threshold — 49.6; 48.6 degrees centigrade

Primary: Mean Peak Dyskinesia Score — 11.00; 11.42; 8.50 Score on a scale

Primary: Maximum Tolerated Dose of Lenalidomide Defined as the Dose Level at Which 0/6 or 1/6 Subjects Experience Dose Limiting Toxicity (DLT) With the Next Higher Dose Having at…

Primary: Aided Speech Reception Threshold (SRT) in Noise Measured by Signal to Noise Ratio for 50% Correct Scores With the Oldenburger Sentence Test — -0.83; -1.45; 0.64; 0.89 dB…