Phase 4 N=250 Pain Control In First Trimester Medical Abortion: A Randomized Trial
Pain
Primary: 11-point Visual Analog Scale for Pain — 7.1; 7.3 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=30 A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both
Hepatitis B, Chronic
Primary: Mean Change From Baseline in Viral Quantitative e Antibody — 0.07; 0.15; 0.02; 0.03 Cut-off index (C.O.I.)
N/A N=14 Mindfulness-based Intervention for Teenagers With Cancer
Pediatric Cancer
Primary: Changes in Mood From Baseline to Post-intervention and 6 Months Post-intervention — 18.9; 17.8; 15.9; 12.8 units on a scale — p=0.613
N/A N=60 Safe Critical Care: Testing Improvement Strategies
Central Line-associated Bloodstream Infection (CLABSI) · Ventilator Associated Pneumonia
Primary: CLABSI and VAP Rates — 1.84; 2.42; 2.24; 2.47 events/1000 device days — p=<.05
N/A N=100 A Trial of Mechanical Axis vs Kinematic Alignment in Total Knee Replacement
Arthroplasties · Knee Replacement
Primary: Oxford Knee Score — 20.3; 21.1; 32.5; 32.8 units on a scale — p=<0.0001
Phase 1 N=10 Safety Study of Octreotide Injection to Prevent GI Bleeding in Patients With Left Ventricular Assist Device (LVAD)
Gastrointestinal Bleeding
Primary: Number of Participants With Side-Effects — 10 participants
Phase 2 N=33 Pazopanib in Patients With Relapsed or Refractory Small Cell Lung Cancer
Small Cell Lung Cancer · Lung Cancer · SCLC
Primary: 8-Week Progression-Free Rate — 0.567 proportion of patients
N/A N=25 Comparison of the Airway Clearance Efficacy of Electro Flo 5000 and the G5 Flimm-Fighter in Patients With CF
Cystic Fibrosis
Primary: Wet Sputum Weight — 5.22; 4.19 gram
Phase 4 N=73 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding
Herpes Simplex Type II
Primary: HSV Shedding Rate in Those Receiving Oral TDF, Vaginal TFV, or Double Placebo — 22.9; 13.8; 21.3; 19.5 percentage of swabs positive (%) — p=0.086
Phase 3 N=350 A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellitus
Diabetes · Diabetes Mellitus, Type 1
Primary: Change From Baseline in HbA1c (Glycosylated Haemoglobin) (%) at 26 Weeks (Analysed by Central Laboratory) — -0.20; -0.31 percentage of glycosylated haemoglobin
N/A N=605 Drug Concentration, Immunogenicity, and Efficacy Study in Patients With Rheumatoid Arthritis Currently Treated With Etanercept, Adalimumab, or Infliximab
Rheumatoid Arthritis
Primary: Percentage of Participants Positive for Antidrug Antibodies Among Those Treated With Etanercept Versus Those Treated With Monoclonal Antibodies (Adalimumab or…
N/A N=52 Stryker Triathlon Total Knee System for Total Knee Arthroplasty Implanted Using Shapematch Cutting Guides:Sub-Study A
Arthroplasties, Replacement, Knee
Primary: Repeatability of Cutting Guide Position — 0.990; 0.963; 0.936; 0.910 intraclass correlation coefficient (ICC)
N/A N=127 Investigation of Newly Developed Ostomy Products in Subjects With Ileostomy
Stoma Ileostomy
Primary: Degree of Leakage — 5.1; 5.8 units on a scale
Phase 3 N=62 Bipolar Depression Before and After Lamotrigine Treatment
Bipolar Depression
Primary: Mean Montgomery-Åsberg Depression Rating Scale (MADRS) Score at Baseline for Both Groups, and After 12 Weeks of Lamotrigine Monotherapy for the Bipolar Group — 27.79…
Phase 3 N=356 A Study Evaluating the Efficacy and Safety of BOTOX® or Solifenacin in Patients With Overactive Bladder and Urinary Incontinence
Overactive Bladder · Urinary Incontinence
Primary: Change From Study Baseline in Number of Episodes of Urinary Incontinence in Treatment Cycle 1 — 4.86; 5.23; 4.38; -3.10 Incontinence Episodes