65,437 trials
Multiple Myeloma
Primary: Percentage of Participants With an Objective Response According to International Myeloma Working Group (IMWG) Uniform Response Criteria Based on Investigator Assessment…
Healthy
Primary: Faldaprevir: Area Under the Curve Over the Time Interval From 0 Extrapolated to Infinity (AUC 0-infinity) — 37900; 48200; 36000 [ng*h/mL] — p=0.3420
Metastatic Breast Cancer
Primary: Percentage of Participants With Adverse Events (AE), Serious Adverse Events (SAE), AEs With Grade >=3, and AEs Related To Treatment — 100; 100; 100; 100 percentage of…
Bipolar Disorder
Primary: Young Mania Rating Scale (YMRS), — 19.61; 7.06; 5.68 units on a scale
Metastatic Osteosarcoma · Recurrent Adult Soft Tissue Sarcoma · Recurrent Osteosarcoma
Primary: Progression-free Survival Rate, Defined as CR + PR + SD, as Assessed by RECIST Criteria — 4; 57; 98 participants
Knee Osteoarthritis · Symptomatic Knee Osteoarthritis
Primary: Change in Isotonic Double Leg-press 1 Repetition Maximum Strength Scaled to Body Mass — 0.2; 0.4 kg per kg body mass
Venous Insufficiency · Venous Reflux · Lower Extremity Ulcer
Primary: Wound Area Mean Percent Reduction — 45.8; 61.6 percentage of mean area reduction — p=<0.024
Rheumatoid Arthritis
Primary: Number of Participants With American College of Rheumatology Response of 20 (ACR20) at 16 Weeks — 22; 20; 23; 18 Participants
Healthy Volunteers
Primary: Percentage of Radioactive Dose of [14C] Radiolabelled AZD9291 Recovered in Urine, Faeces, and in Total. — 14.2; 67.8; 81.9 Percentage radioactive dose recovered
Accidental Falls
Primary: Wheelchair-related Falls — 545; 165 participants — p=0.033
Shift-Work Sleep Disorder · Insomnia · Restless Leg Syndrome
Primary: Firefighters' Health, as Determined by Number of 'Sick' Days Over 12 Months — 3.1; 3.2; 1.4; 2.6 days/firefighter — p=0.66
Myopia
Primary: Spherical Equivalent Refraction — -0.326; -0.460; -0.430; -0.898 diopter (D)
Nicotine Dependence
Primary: Continuous Four-week Abstinence From Smoking — 7 participants
Breast Augmentation
Primary: Investigator Overall Satisfaction With the Device Using a 5-Point Scale — 4.6 score on a scale
Myopia
Primary: Axial Length (Axial Elongation) — 0.158; 0.144; 0.121; 0.242 millimeter (mm)