65,437 trials
Primary Biliary Cholangitis · Liver Stiffness
Primary: Change in ALP at Week 24 Compared to Baseline — 0.89; 0.84; 1.03 ratio — p=0.0206
Hypertension
Primary: Primary Outcome: Change in Mean Sitting SBP — -19.2 mmHg — p=< 0.001
Stroke · Depression
Primary: Change in Mean Score of Depression as Assessed by the Hamilton Rating Scale for Depression — 5.20; 2.17; 0.14 units on a scale
Colorectal Cancer · Colorectal Neoplasms · Colorectal Carcinoma
Primary: Percentage Change From Baseline in Tumour Size — 8.3; 2.9; 3.2; 2.3 Percent change
Chronic Kidney Disease(CKD)
Primary: Percentage of Daily Doses of Medication Taken as Prescribed (Medication Adherence) — 98; 74 percentage of Daily doses — p=.04
Developmental Disability
Primary: Change in Participation-related Goal Performance and Satisfaction — 3.67; 3.72; 4.92; 4.69 score on a scale — p=0.05
Study Vasodilatory Effects of C21
Primary: Percentage Change From Baseline in Forearm Blood Flow in Response to Increasing Intraarterial Doses of C21 — 27.8; 17.2; 37.0; 28.5 percentage of change from baseline
Insomnia · Mild Cognitive Impairment
Primary: Client Satisfaction Questionnaire (CSQ-8) — 29.43 score on a scale
Anxiety Disorders · Depressive Disorder · Eating Disorders
Primary: Effectiveness of the Mobile Mental Health Platform, Compared to Usual Care, in Changing the Number of Individuals With Mental Health Disorders. — 2264; 2274; 839; 828…
Infection
Primary: Antibiotic Prescribing Rate at Index Consultation (Immediate or Delayed) — 466; 817 Participants
Crohn's Disease · Complex Perianal Fistula
Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs) — 40; 43 Participants
Clinical Indication for Brain MRI · Healthy Volunteers
Primary: Sensitivity of Pathological Findings (Full Analysis Set) — 0.66; 0.68 Proportion of participants
Anal High Grade Squamous Intraepithelial Lesion
Primary: Performance Characteristics: Sensitivity (SN), Specificity (SP), Positive Predictive Value (PPV) and Negative Predictive Values (NPV) — 90.0; 76.9; 100.0; 65.6…
Hearing Loss
Primary: Proportion of Participants With SENS-401 Detected in Perilymph — 15; 0 Participants
Healthy
Primary: Pharmacokinetics (PK): Area Under the Concentration-time Curve, From Time 0 to the Time of the Last Quantifiable Concentration (AUClast) of Selpercatinib in Plasma (Part…