12,372 trials
Wrinkles
Primary: Posttreament Results of Chemical Peel if Botox A is Added as Pre-treatment — 1; 2 Units on a wrinkle severity scale — p=.002
Persistent Asthma
Primary: Standardized Baseline-Adjusted Trough Morning Forced Expiratory Volume in One Minute (FEV1) Area Under the Effect Curve From Time Zero to 6 Weeks (AUEC(0-6wk)) — 62…
Rheumatoid Arthritis
Primary: Number of Participants With an American College of Rheumatology 20% (ACR20) Response at Week 14: Period 1 — 198; 207 participants
Diabetes Mellitus
Primary: Change in HbA1c From Baseline to Week 28 — -1.39; -1.98; -1.60 % HbA1c — p=0.003
Heroin Dependence
Primary: Drug Self-administration — 350; 255; 223; 113 Clicks on a computer mouse
Open-Angle Glaucoma · Ocular Hypertension
Primary: Mean Diurnal IOP Change From Baseline at Month 3 — -7.2; -7.3 mmHg
Atrophic Vaginitis
Primary: Primary Endpoint (Vaginal Cytology + Vaginal pH) Equivalence — 42; 45 Participants
Infections, Meningococcal
Primary: Anti-Meningitis Antibody Titers by Serum Bactericidal Assay Using Rabbit Complement (rSBA) — 3415.3; 2860.4; 1577.4; 5092.5 EL.U/mL
Migraine Disorders
Primary: Change From Baseline in the Frequency of Headache Days — 23.2; 23.4; 25.3; -6.3 Headache days
Hidradenitis Suppurativa
Primary: Percentage of Participants in the EW/EW/EW, EW/EOW/EW, and EW/PBO/EW Analysis Populations Achieving Clinical Response Per Hidradenitis Suppurativa Clinical Response…
Alzheimer's Disease
Primary: Change From Baseline in Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) Total Score at Week 48, as a Function of APOE ε4 Status in APOE4 Negatives…
Chronic Hepatitis C · Hepatitis C (HCV) · Hepatitis C Genotype 1a
Primary: Change in Interferon (IFN)-Stimulated Genes (ISG) Expression in Peripheral Blood Mononucleated Cells (PBMCs) for Participants Achieving SVR12 — -0.464; -0.148; -0.611…
Nonalcoholic Fatty Liver Disease (NAFLD)
Primary: Improvement in Nonalcoholic Fatty Liver Disease (NAFLD) — 25; 18 participants — p=0.34
Bronchiectasis
Primary: Time to First Exacerbation Event Within 48 Weeks - Cipro 28 vs. Pooled Placebo — NA; NA Days — p=0.0511
Nicotine Dependence
Primary: The Amygdala, Anterior Insula, and Medial Prefrontal Cortex Scans Will be Compared to Evaluate Significant Differences — 0.057; .007; .160; .129 percent BOLD signal change