12,372 trials
Osteoarthritis, Knee
Primary: Change in Knee Pain as Measured by the WOMAC Osteoarthritis (OA) Index Pain Subscale (Section A, Items #1-5) Measured by 100 mm VAS — -32.0; -25.5 units on a scale…
Dyspnea · Pulmonary Complications · Unspecified Adult Solid Tumor, Protocol Specific
Primary: Dyspnea as Measured by Oxygen Cost Diagram (OCD) — 8.98; 9.32 units on a scale — p=0.080
Rotavirus Gastroenteritis
Primary: Geometric Mean Titer of Serum Neutralizing Antibody Response to Human Rotavirus Serotypes G1, G2, G3, G4, and P1A[8] — 99.8; 106.1; 30.0; 26.3 Titer
Ocular Hypertension · Glaucoma
Primary: Incidence of Primary Open-Angle Glaucoma in Hypotensive Patients — 9.5; 4.4; 20.0; 14.1 percent of participants
Multiple Sclerosis
Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability — 100; 12; 0 Participants
Plaque-type Psoriasis
Primary: Percentage of Participants (Who Achieved a Partial Response Defined as ≥ 50% But < 75% Improvement in Psoriasis Area and Severity Index (PASI) After 12 Weeks of…
Chlamydial Infection
Primary: Assess Microbiological Failure of Recommended Azithromycin and Doxycycline Regimens in Uncomplicated Chlamydia Trachomatis Infection in a Setting Where Repeat Exposure…
Chronic Obstructive Pulmonary Disease
Primary: Trough Forced Expiratory Volume in One Second (FEV1) Following 26 Weeks of Treatment to Demonstrate the Non-inferiority of QVA149 110/50 μg o.d. to…
Acute Coronary Syndrome · Adverse Reaction to Antiplatelet Agent
Primary: Residual Platelet Reactivity — 168; 252 PRU (P2Y12 reaction units) — p=0.006
Hypoxia
Primary: Episodes of Intermittent Hypoxia Per Hour — 3.6; 8.4; 3.8; 8.2 Events per hour — p=<0.05
Ankylosing Spondyloarthritis
Primary: Percentage of Participants Who Achieved an Assessment of SpondyloArthritis International Society 20 (ASAS 20) Response at Week 16 — 36.6; 35.0; 32.5 Percentage of…
Acute Coronary Syndrome · Acute Myocardial Infarction
Primary: Clinical Performance - Area Under the Curve — 0.9326; 0.9197; 0.9412; 0.9431 Probability
Macular Degeneration
Primary: Change From Baseline in Best Corrected Visual Acuity (BCVA) as Measured by ETDRS Letter Score at Week 28 - Last Observation Carried Forward (LOCF) — 14.0; 3.9 Letters…
Glaucoma
Primary: Adverse Events — 100; 16.67 percentage of participants
Diabetic Peripheral Neuropathy · Pain
Primary: Percent Change in the Average Daily Pain Score From Baseline to Between Weeks 2 and 8 — -27.44; -20.85 percentage change — p=0.025