Early Phase 1 N=102 The Effects of IQOS Use on Cigarette Smoking Behaviors
Smoking · Cigarette Smoking · Tobacco Use
Primary: Cigarette Consumption — 31.68 percentage of baseline smoking rate
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=30 Behavior Brain Responses
Alcohol Drinking · Drinking Behavior · Physiological Effects of Drugs
Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions…
Early Phase 1 N=16 Neoadjuvant Imiquimod Immunotherapy for Oral Cancer
Oral Squamous Cell Carcinoma
Primary: Number of Participants With 50% Reduction in Tumor Cell Count and Major Pathologic Response — 9; 6 Participants
Early Phase 1 N=57 Classroom Activities
Physical Activity
Primary: Change in Use of Movement Integration Strategies (Mean Per Day) — 0.4; 0.1; 0.8 Change in movement strategy use per day
Early Phase 1 N=20 An Exploratory Study of ZB-06 as a Vaginal Contraceptive Film
Contraception
Primary: Surrogate Contraceptive Efficacy — 25.86; 0.04; 47.39 sperm per high power field — p=<0.0001
Early Phase 1 N=28 Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage
Intracerebral Hemorrhage · Cerebral Edema · Stroke Hemorrhagic
Primary: Number of Participants With Clinically Significant Cardiac Events — 3; 0; 0 Participants — p=0.0427
Early Phase 1 N=138 Drugs Brain and Behavior (DDP)
Stimulant Use
Primary: Change in SUbjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ). — 19.2; 57.8…
Early Phase 1 N=26 Sex Differences in the Dilatory Response of Compound 21
Sex Differences
Primary: Microvascular AT2R Sensitivity Following Local Control Treatment — 15; 25 percentage of maximal blood flow
Early Phase 1 N=34 Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
Metabolic Acidosis · Chronic Kidney Disease · Cognitive Dysfunction
Primary: Change in Cognitive Function Composite Score at 12 Months — 52.3; 47.3; 53.5; 49.3 T-score
Early Phase 1 N=229 Comparison of 0.1 and 0.05mg Intrathecal Morphine for Post-cesarean Analgesia.
Cesarean Section
Primary: Time to First Narcotic Rescue Dose in the First 24 Hours Post-cesarean Delivery. — NA; 23.5 hours
Early Phase 1 N=22 Clinical Evaluation of the Pharmacokinetic Goldenseal-Metformin Interaction in Diabetic Patients
Interaction, Adverse Herb-Drug · Diabetes Mellitus, Type 2
Primary: Metformin AUC — 59.6; 54.5; 57.3 mcg*hr/mL
Early Phase 1 N=188 Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
Obstructive Sleep Apnea · Tonsillitis
Primary: Number of Patients Requiring Rescue Intravenous Opioid — 48; 66 Participants
Early Phase 1 N=124 Boost Study 21270 (Cognition)
Cognitive Function Abnormal
Primary: Task Completion Rate — 66; 57 Percentage of eligible participants
Early Phase 1 N=12 A Microdose Evaluation Study of ABY-029 in Recurrent Glioma
Glioma
Primary: Fluorescence Signal Detection — 6.2; 5.0; 8.8 Biological variance ratio
Early Phase 1 N=25 Imaging the Neurochemistry of Drug Addiction With PET
Smoking · Cannabis
Primary: Change in Dopamine Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images. — 0.0388; 0.033; 0.0285; 0.0368 mm^3