Phase 4 N=26 NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial
Epistaxis
Primary: Frequency of Epistaxis — -1.68; 1.14 Nosebleeds per week — p=0.16
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=60 Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)
Aortic Stenosis · Inflammation · Thrombosis
Primary: Platelet Reactivity — 275.5; 251; 234; 128.5 Platelet Reactivity Units
Phase 4 N=15 Evaluation of the Fluoride Dose Response Using In Situ Caries Model
Caries
Primary: Enamel Fluoride Uptake (EFU) — 2.28; 4.51; 8.78; 14.05 μg F/cm^2
Phase 4 N=756 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries
Postpartum Sepsis · Postpartum Endometritis · Postpartum Fever
Primary: Number of Participants Who Experienced Composite Peripartum Infection or Death — 15; 17; 24 Participants
Phase 4 N=167 Efficacy and Safety of EXPAREL Versus Standard of Care (SoC) in Subjects Undergoing Elective Cesarean Section
Elective Cesarean Section · Pain Management
Primary: Total Postsurgical Opioid Consumption Through 72 Hours — 69.3; 36.1; 22.1 OMED mg
Phase 4 N=11 Effect of Fosaprepitant on Motor Evoked and Somatosensory Evoked Potentials Under General Anesthesia
Postoperative Nausea
Primary: Somatosensory Evoked Potentials (SEPs), Extremity Amplitude (Left Upper Extremity) — 2.685; 2.545; 2.58; 2.292 µV — p=0.35
Phase 4 N=150 Local Anesthetics for Pain Reduction Prior to IV Line Placement
Pain · Local Anesthesia for Peripheral Intravenous Catheterization
Primary: Pain Score Following Anesthetic Administration — 2.81; 1.64; 2.05 units on a scale
Phase 4 N=15 Apremilast for RAS
Recurrent Aphthous Stomatitis
Primary: Duration of RAS Lesions — 1.57 weeks
Phase 4 N=260 Sugammadex vs Placebo to Prevent Residual Neuromuscular Block
General Surgery
Primary: Decreased Minute Ventilation (MV) — 20; 26 Participants
Phase 4 N=168 A Study to Evaluate Androderm®'s Effect on Blood Pressure in Adult Hypogonodal Male Participants
Hypogonadism
Primary: Change From Baseline in 24-hour Average Systolic Blood Pressure (SBP) Obtained at Week 16 — 123.2; 3.5 millimeters of mercury (mmHg)
Phase 4 N=10 Senescent Immunity in Elders and Vaccine Responses (SILVER)
Flu Vaccine
Primary: Hemagglutinin Antigen Inhibition Assay Titers at Baseline — 20; 160; 25; 40 antibody titers
Phase 4 N=14 Exercise Pulmonary Transit Time
Heart Failure, Diastolic
Primary: Pulmonary Transit Time — 2.5 seconds
Phase 4 N=44 An Analysis of the Efficacy of a Pre-Emptive Multimodal Pain Regimen in Reducing Acute Post-Operative Pain and Narcotic Pain Medication Requirements in Spine Surgery
Pain, Postoperative · Spine Injuries and Disorders · Narcotic Use
Primary: Visual Analogue Scale (VAS) for Pain — 4.8 score on a scale
Phase 4 N=66 Progesterone and Brain Imaging Study
Nicotine Dependence · Nicotine Withdrawal
Primary: GABA Pre and Post Progesterone Administration (Dorsal Anterior Cingulate Cortex [DACC]) — 1.23; 1.17; 1.28; 1.24 mg/dl
Phase 4 N=50 Efficacy of Liposomal Bupivacaine for Prolonged Postoperative Analgesia in Patient Undergoing Breast Reconstruction With Tissue Expander
Pain, Postoperative · Mammaplasty
Primary: 1 Hour Pain Assessment Numeric Rating Scale During Rest — 5; 5 units on a scale — p=.87