Phase 4 N=9 Ketamine Treatment Effects on Synaptic Plasticity in Depression
Major Depressive Disorder
Primary: Synaptic Density — 2.40; 2.32 Ratio
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=259 Addressing Palliative Care Needs Among Intensive Care Unit Family Members
Critical Illness · Family Members · Psychological Distress
Primary: Needs; Existential Concerns; Symptoms; and Therapeutic Interaction (NEST) Scale Total Score — 36.9; 36.3; 26.5; 32.3 score on a scale — p=0.018
N/A N=33 Effects of Light on Melatonin and Contractions in Pregnant Women
Pregnancy
Primary: Melatonin Area Under the Curve (AUC) — 42.1; 24.3; 38.5; 26.3 area under curve (h*pg/mL) — p=0.334
Phase 2 N=24 Contrast-Enhanced Ultrasound for Kidney Cancer Subtyping and Staging
Kidney Cancer
Primary: 3D CEUS Generated Metrics in Kidney Mass: Wash_In_Slope — 7.60 AU/second
N/A N=249 Tambua Mapema Plus - to Discover HIV Infection Early and Prevent Onward Transmission
HIV Infections
Primary: Proportion of Patients With Newly Diagnosed HIV Infection at Care Seeking — 50; 13; 37; 2 Participants
Phase 3 N=60 Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF
Coronary Artery Bypass · Cardiopulmonary Bypass · Coronary Artery Disease
Primary: Plasma Troponin I at Baseline — 0.42; 0.17 ng/mL — p=0.993
Phase 3 N=763 A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
Chronic Obstructive Pulmonary Disease
Primary: Least Square (LS) Mean Change From Baseline in Average Forced Expiratory Volume in 1 Second (FEV1) Area Under the Curve Over 12 Hours (AUC0-12h) at Week 12 — 0.0611…
Phase 1 N=128 Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma · Hepatocellular Carcinoma · Liver Cancer
Primary: Part 1, Dose Escalation Phase: Number of Participants With Dose-limiting Toxicities (DLTs) Based on National Cancer Institute (NCI) Common Terminology Criteria for…
N/A N=120 Multimodal Sleep Intervention Using Wearable Technology
Drinking, Alcohol
Primary: Total Alcohol Drinks Consumed Over the 12wk Followup — 3.07; 2.95; 2.96 log-transformed total alcohol drinks — p=0.75
N/A N=40 The Acute Effect of Vaping on Food Intake
Energy Intake · Food Intake · E-Cig Use
Primary: Energy Intake — 1102.1; 1003.4; 910.4; 868.3 Kilocalories
N/A N=100 Dexcom Continuous Glucose Monitoring in Long-term Care
Diabetes · Diabetes Mellitus, Type 2
Primary: Number of Participants Experiencing Hypoglycemia (BG<70 mg/dL) — 4; 9 Participants
N/A N=71 A Clinical Evaluation of the MINI TREK RX 1.20 mm Coronary Dilatation Catheter in Stenotic Lesions
Ischemic Heart Disease · Coronary Artery Stenosis · Chronic Coronary Total Occlusion
Primary: Percentage of Participants With Procedure Success — 98.5 percentage of participants
Phase 3 N=187 Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Primary: Change in Pulmonary Vascular Resistance (PVR) Expressed as the Ratio of Geometric Means of End of Double-blind Treatment (EDBT) to Baseline — 0.77; 0.55; 0.78; 0.56…
N/A N=85 Exploring the Effect of Rumination-Focused Cognitive Behaviour Therapy in Patients With Schizophrenia
Randomized Controlled Trial
Primary: Beck Depression Inventory (BDI-II) — 16.89; 16.88; 16.60; 18.70 score on a scale
N/A N=355 Enhanced Quality in Primary Care for Elders With Diabetes and Dementia
Diabetes · Dementia · Alzheimer Disease
Primary: Percent of Patients Who Reach Consensus Target HBA1c — 12; 18.75 percentage of participants