Clinical Trial Search

Primary: Adult ADHD Investigator Symptom Rating Scale (AISRS) Score at End of Placebo Lead-In — 37.2 score on a scale

Primary: Attention Deficit Hyperactivity Disorder Total Symptom Score — 21.4; 30.0; 20.2; 29.7 units on a scale — p=<0.05

Primary: Efficacy and Safety of SPN-810 on the Frequency of Impulsive Aggression (IA) Measured by the Impulsive Aggression Diary — -48.16; -47.88; -58.56 percent change of IA…

Primary: Change From Baseline at Week 4 in ADHD Symptoms Measured With the ADHD Rating Scale Version IV With Adult Prompts (ADHD RS IV) — -12.38; -13.88; -9.7 units on a scale…

Primary: Attention Deficit / Hyperactivity Disorder Total Sum Score of All 18 ADHD Symptom Items — 26.54; 25; 18.94; 18.46 Score

Primary: Dyadic Parent-Child Interaction Coding System (DPICS) - Behavior Counts — 67.2; 42.1; 53.8; 40.1 behaviors

Primary: Number of Participants That Tested High (6 or More Symptoms) for ADHD by Type Determined by Adult ADHD DSM IV-TR Checklist — 2; 5; 2 Participants

Primary: Efficacy and Safety of SPN-810 on the Frequency of Impulsive Aggression (IA) Measured by the Impulsive Aggression Diary — -54.12; -51.64 Percent Change of IA behaviors…

Primary: Total ADHD Symptom Score From Vanderbilt ADHD Parent Rating Scale — 27.00; 26.63 units on a scale — p=.36

Primary: Change From Baseline in Total Score of Barratt Impulsiveness Questionnaire v.11 (BIS-11) After Single Dose (at Day 1) — -0.8; -0.4 Score on a scale

Primary: Change From Baseline in Severity of Attention Deficit Hyperactivity (ADHD) Symptoms — -11.1; -18.2; -18.1 score on a scale

Primary: ADHD Severity — -20.6; -21.8 units on a scale

Primary: Change From Baseline in Total AISRS Score at the End of Double-blind Treatment (Week 8) — -17; -17 units on a scale

Primary: ADHD Rating Scale IV — 18.0; 21.3 units on a scale

Primary: Mood Severity Index Measures Severity of Mood Symptoms (MSI).Range of 0-116; Clinicians Give to Parents and Child to Get Composite Score; Higher Scores=Greater Severity…

Primary: Change in fMRI Measure — -0.957100; 0.572517; -0.139000; 1.876717 BOLD signal

Primary: Improvement in ADHD Severity From Baseline to End of Intervention — 3.0; 3.2 units on a scale

Primary: Child Behavioral Functioning — 4.78; 4.56; 4.44; 4.67 units on a scale

Primary: Change From Baseline in the Oppositional Subscale of the Conners' Parent Rating Scale-Revised Long Form (CPRS-R:L) Score at Up to 8 Weeks — -10.8; -7.0 Units on a scale…

Primary: Parent Outcome-Vanderbilt ADHD Parent Rating Scales (VADPRS) — 1.10; 1.47; .84; 1.14 units on a scale

Primary: Inattention Subscale — -13.71; -16.18 units on a scale

Primary: Social Behavior-Negative Verbalizations — 73.32; 45.41; 28.41; 15.08 Number of Observed Behaviors

Primary: Changes in Attention Deficit Hyperactivity Disorder (ADHD) Symptoms - Adolescent Report — -4.27; -0.55 units on a scale — p=<.0001

Primary: ADHD Symptoms — 71.2; 78.4; 47.4; 55.5 Percent of item endorsement — p=<0.025

Primary: Mean Conners' Teacher ADHD Index T Score by Dose — 72.8; 63.1; 63.6; 61.5 Units on a scale (T-scores) — p==.001

Primary: Total ADHD Symptom Score From Vanderbilt ADHD Parent Rating Scale — 25.94; 28.28 units on a scale — p=.35

Primary: Number of High-effort Selections in the Effort-based Decision Making Task — 16.4; 21.35; 20.45; 19.8 Number of high-effort selections

Primary: Sleep Duration — 609.57; 602.79 minutes — p=<.05

Primary: DSM-IV ADHD Rating Scale (AISRS) Score Change — -17.5; -10.6; -6.9 Units on a scale

Primary: Change in Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) Attention-deficit/Hyperactivity Disorder (ADHD) Checklist — 18.61; 18.19 units on a…