N/A N=1,799 EHR-based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care
Appendicitis
Primary: Pre to Post Ratio of Image Use — 1.13; 1.07; 1.03; 1.01 ratio of pre-post use
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=20 Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses
Abdominal Abscess · Pelvic Abscess
Primary: Percentage of Patients Requiring Surgical Debridement for a Persistent Abscess Within 30 Days Following Initial Drainage — 3; 7 participants
Phase 2 N=80 Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension
Acute Pancreatitis · Intra-abdominal Hypertension
Primary: Percent Change of IAP After Treatment — -18.7; -5.4; -27.2; -20.0 percent change of IAP
Phase 4 N=14 ABRA Abdominal Closure System in Open Abdomen Management
Open Abdomen
Primary: Primary Closure Rate — 75; 67 % of participants
Phase 3 N=891 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT
Appendicitis
Primary: Negative Appendectomy — 6; 6; 166; 180 participants
Phase 4 N=393 Acetaminophen (APAP) +/- Oxycodone
Musculoskeletal Pain
Primary: Change in Pain Assessment — 2.9; 4.0 score on a scale
Phase 2 N=216 A Study of Auxora in Patients With Acute Pancreatitis and Accompanying SIRS
Acute Pancreatitis · Systemic Inflammatory Response Syndrome
Primary: Median Time to Solid Food Tolerance, With gMCP Modeling Analysis for Dose-response Relationship — 67.0; 64.0; 78.0; 66.0 Hours — p=0.3184
Phase 2 N=54 Study in Subjects Undergoing Complete Abdominoplasty
Postsurgical Pain
Primary: Pain Intensity Scores at 96 Hours at Rest Using Numerical Rating Scale (NRS) — 2.8; 2.0; 3.0; 2.8 score on a scale — p=0.2912
N/A N=168 Magnetic Resonance Imaging Study of Acute Pancreatitis
Acute Pancreatitis
Primary: The T2* Values in the Diagnosis of AP — 25.86; 21.06 ms — p=<0.01
Phase 3 N=56 Early Short-term Antibiotic Therapy in Penetrating Abdominal Trauma, 3 vs 7 Days
SURGICAL SITE INFECTION
Primary: Surgical Site Infection — 6; 3 participants — p=<0.05
Phase 2 N=32 Antibiotic Instillation in Appendicitis
Complicated Appendicitis · Acute Appendicitis
Primary: Feasibility of the Use of Antibiotic Solution Instillation Following Intraoperative Diagnosis of Complex Appendicitis as Assessed by Percentage of Eligible Participants…
Phase 3 N=541 Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal Infections
Complicated Intra-abdominal Infections
Primary: Clinical Response of Eravacycline and Ertapenem Treatment Arms at the Test-of-cure (TOC) Visit in the Microbiological Intent-to-treat (Micro-ITT) Population — 191; 198…
N/A N=278 Post-operative Patient Positioning Device for Improvement of Post-Operative Pain
Pain, Postoperative
Primary: Total Morphine Milliequivalent (MME) Use Postoperatively After Cesarean Delivery — 52; 68 Morphine milligram equivalents
Phase 2 N=143 Study to Compare TP-434 and Ertapenem in Community-acquired Complicated Intra-abdominal Infections
Complicated Intra-abdominal Infection
Primary: Clinical Response to TP-434 and Ertapenem in the Microbiologically Evaluable (ME) Population at the Test-of-Cure Visit — 39; 41; 24; 3 participants
Phase 4 N=87 Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole
Dyspepsia · Emergency · Pain
Primary: Pain Scores on the 100-millimeter Visual Analog Scale (VAS) at 1 Hour After Treatment — 17; 19 millimeter — p=0.6
Phase 3 N=500 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections
Complicated Intra-abdominal Infections · Complicated Appendicitis
Primary: Number of Participants With a Favorable Clinical Response at the Test-of-Cure (TOC) Visit in the Microbiological Intent-to-treat (Micro-ITT) Population — 177; 187; 7; 7…
Phase 4 N=128 Prospective, Double Blind, Placebo Control, Bariatric IV Ace
Obesity
Primary: Quality of Recovery-15 Patient Survey — 107.2; 108.6; 118.3; 117.1 units on a scale — p=0.59
Phase 4 N=40 Optimal Care of Complicated Appendicitis
Appendicitis · Perforated Appendicitis · Ruptured Appendicitis
Primary: Overall Cost of Care
N/A N=283 Open Abdomen Study Comparing ABThera™ Open Abdomen Negative Pressure Therapy System and Barker's Vacuum Packing Technique
Open Abdomen
Primary: Number of Participants With Primary Fascial Closure — 139; 69 Participants — p=0.06
N/A N=30 Intra-Abdominal Hypertension in Neonatal Intensive Care Patients
Intra-Abdominal Hypertension
Primary: Intra-abdominal Pressure(IAP) Measurements in NICU Patients. — 1219 IAP measurements
Phase 3 N=219 Evaluation of N1539 Following Abdominoplasty Surgery
Pain, Post-operative
Primary: Summed Pain Intensity Difference Over the First 24 Hours (SPID24) — -4262.1; -3535.7 units on a scale — p=0.0145
N/A N=98 Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
Appendicitis · Appendicitis; Perforation
Primary: Length of Hospital Stay — 121.55; 131.69 hours
N/A N=45 BULLET: Bladder Ultrasound Limits Length (of Time), Expedites Treatment
Point-of-Care Bladder Ultrasound · Urethral Catheter
Primary: Time to Successful Completion of Pelvic Ultrasound — 103.95; 92.82 minutes
Phase 3 N=458 Moxifloxacin in Pediatric Subjects With Complicated Intra-abdominal Infection
Intraabdominal Infections
Primary: Number of Subjects With Adverse Events — 175; 82; 20; 6 Subjects
Phase 3 N=804 Therapy of Complicated Intra-Abdominal Infections With Moxifloxacin or Ertapenem
Infection
Primary: Number of Subjects Achieving Clinical Cure at Test of Cure (TOC) Visit in the Per Protocol Population — 315; 324; 37; 23 participants
Phase 3 N=42 A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis
Acute Pancreatitis
Primary: Systemic Inflammatory Response Syndrome (SIRS) Score — -0.96; -1 score on a scale — p=0.87
N/A N=100 Gastric Ultrasound
Surgery
Primary: Aspiration Risk Grade — 30; 30; 20; 9 Participants
N/A N=541 Assessment of Acute Disease to Reduce Imaging Costs
Acute Coronary Syndrome · Pulmonary Embolism
Primary: Efficiency--Mean Cost of Care — 3933; 2761 US Dollars
N/A N=90 The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
Perforated Appendicitis
Primary: Time Until PCA Discontinued After the Operation — 76.4; 86.7 hours
N/A N=4,003 Personalized Recommendations for Acute Kidney Injury (AKI) Care
Acute Kidney Injury
Primary: Composite Outcome Showing the Percentage of Participants With Any One of the Following: Progression of AKI, Inpatient Dialysis, or Inpatient Death — 369; 395…